Lifespan Health and Performance Laboratory, York University, Toronto, Ontario.
Can Respir J. 2010 Sep-Oct;17(5):e97-101. doi: 10.1155/2010/679716.
To determine whether age at asthma diagnosis has an impact on the previously described relationship between asthma and obesity.
Data were provided from Cycle 1.1 (2000⁄2001) of the Canadian Community Health Survey, a nationally representative health survey that included 6871 participants (2464 males and 4407 females) with asthma. Body mass index was used to categorize participants as normal weight (18.5 kg/m2 to 24.9 kg/m2), overweight (25 kg/m2 to 29.9 kg/m2) or obese (30 kg/m2 or greater). Multivariate logistic regression analyses were used to estimate the odds of overweight and obesity by self-reported age at asthma diagnosis, after accounting for current age and other covariables.
In fully adjusted models, males diagnosed with asthma during adolescence (12 to 20 years of age) were at elevated odds of obesity (OR 1.58; 95% CI 1.03 to 2.43) compared with asthmatic patients diagnosed during childhood (0 to 11 years of age). Women diagnosed with asthma in mid life (21 to 44 years of age) and later life (45 to 64 years of age) were 43% (OR 1.43; 95% CI 1.08 to 1.90) and 56% (OR 1.56; 95% CI 1.00 to 2.44) more likely to be obese than those diagnosed in childhood, respectively.
The impact of age at asthma diagnosis on the asthma-obesity relationship differed between males and females. However, the identification of high-risk groups of asthmatic patients may strengthen primary prevention strategies for obesity and related comorbidities at multiple levels of influence.
确定哮喘的发病年龄是否会影响先前描述的哮喘与肥胖之间的关系。
数据来自加拿大社区健康调查的第 1.1 循环（2000/2001 年），这是一项全国代表性的健康调查，包括 6871 名哮喘患者（2464 名男性和 4407 名女性）。体重指数用于将参与者分为正常体重（18.5kg/m2 至 24.9kg/m2）、超重（25kg/m2 至 29.9kg/m2）或肥胖（30kg/m2 或更高）。采用多变量逻辑回归分析，在考虑到当前年龄和其他协变量后，估计根据自我报告的哮喘发病年龄，超重和肥胖的几率。
在完全调整的模型中，青春期（12 至 20 岁）确诊哮喘的男性患肥胖症的几率较高（比值比 1.58；95%置信区间 1.03 至 2.43），而儿童期（0 至 11 岁）确诊哮喘的患者。中年（21 至 44 岁）和老年（45 至 64 岁）确诊哮喘的女性肥胖的几率分别高出 43%（比值比 1.43；95%置信区间 1.08 至 1.90）和 56%（比值比 1.56；95%置信区间 1.00 至 2.44）。
哮喘发病年龄对哮喘与肥胖关系的影响在男性和女性之间存在差异。然而，确定高危哮喘患者群体可能会加强肥胖症和相关合并症的多层面一级预防策略。
