Ramírez-Palacios Luis Román, Reséndez-Pérez Diana, Rodríguez-Padilla Maria Cristina, Saavedra-Alonso Santiago, Real-Najarro Olga, Fernández-Santos Nadia A, Rodriguez Perez Mario A
Laboratorio Estatal de Salud Pública de Oaxaca, Oaxaca.
Departamento de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
Res Rep Trop Med. 2018 Apr 6;9:49-62. doi: 10.2147/RRTM.S144075. eCollection 2018.
Multiple factors have been associated with the severity of infection by influenza A(H1N1)pdm09. These include H1N1 cases with proven coinfections showing clinical association with bacterial contagions.
The objective was to identify H1N1 and copathogens in the Oaxaca (Mexico) population. A cross-sectional survey was conducted from 2009 to 2012. A total of 88 study patients with confirmed H1N1 by quantitative RT-PCR were recruited.
Total nucleic acid from clinical samples of study patients was analyzed using a TessArray RPM-Flu microarray assay to identify other respiratory pathogens.
High prevalence of copathogens (77.3%; 68 patients harbored one to three pathogens), predominantly from , , , and , were detected. Three patients (3.4%) had four or five respiratory copathogens, whereas others (19.3%) had no copathogens. Copathogenic occurrence with was 5.7%, Coxsackie virus 2.3%, 1.1%, 1.1%, and parainfluenza virus 3 1.1%. The number of patients with copathogens was four times higher to those with H1N1 alone (80.68% and 19.32%, respectively). Four individuals (4.5%; two males, one female, and one infant) who died due to H1N1 were observed to have harbored such copathogens as , , , and .
In summary, copathogens were found in a significant number (>50%) of cases of influenza in Oaxaca. Timely detection of coinfections producing increased acuity or severity of disease and treatment of affected patients is urgently needed.
多种因素与甲型H1N1pdm09流感感染的严重程度相关。这些因素包括经证实合并感染且显示与细菌感染存在临床关联的H1N1病例。
目的是确定瓦哈卡州（墨西哥）人群中的H1N1及合并病原体。于2009年至2012年进行了一项横断面调查。共招募了88例经定量逆转录聚合酶链反应确诊为H1N1的研究患者。
使用TessArray RPM-Flu微阵列分析法对研究患者临床样本中的总核酸进行分析，以鉴定其他呼吸道病原体。
检测到合并病原体的高流行率（77.3%；68例患者携带一至三种病原体），主要来自[此处原文缺失病原体名称]。3例患者（3.4%）有四种或五种呼吸道合并病原体，而其他患者（19.3%）没有合并病原体。与[此处原文缺失病原体名称]合并致病的发生率为5.7%，柯萨奇病毒为2.3%，[此处原文缺失病原体名称]为1.1%，[此处原文缺失病原体名称]为1.1%，副流感病毒３型为1.1%。合并病原体患者的数量是仅感染H1N1患者的四倍（分别为80.68%和19.32%）。观察到4例（4.5%；2名男性、1名女性和1名婴儿）因H1N1死亡的个体携带[此处原文缺失病原体名称]等合并病原体。
总之，在瓦哈卡州大量（>50%）流感病例中发现了合并病原体。迫切需要及时检测导致疾病敏锐度或严重程度增加的合并感染并治疗受影响的患者。
