Faculty of Veterinary Science, The University of Melbourne, Werribee, Vic., Australia.
Parasite Immunol. 2010 Nov-Dec;32(11-12):701-9. doi: 10.1111/j.1365-3024.2010.01231.x.
Research undertaken over the past 40 years has established many of the general principals concerning immunity to taeniid cestodes. Although much is well understood about the host-protective mechanisms against taeniids and this knowledge has been exploited in studies on vaccine development, many aspects require further investigation or confirmation. Some phenomena have come to be regarded as being well established, while careful analysis of the published data would suggest that they may be better regarded as hypotheses rather than established facts. This review considers one selected issue pertaining to immunity to cestode infections and examines carefully the nature of the evidence that is available to support conclusions that have been made in this area. The issue examined is the use of Taenia crassiceps as a model for cysticercosis in pigs caused by Taenia solium, together with the S3Pvac vaccine, which has been developed based on this model. Strong evidence is found to support the conclusion that defined T. crassiceps antigens can limit intraperitoneal proliferation of the ORF strain of T. crassiceps in mice; however, the potential for these antigens to affect T. solium infection in pigs requires further confirmation.
在过去的 40 年中，已经进行了许多关于绦虫免疫的研究，确立了许多一般原则。尽管人们对宿主针对绦虫的保护机制有了很多了解，并且这方面的知识已经被应用于疫苗开发的研究中，但许多方面仍需要进一步研究或证实。有些现象已经被认为是既定事实，但仔细分析已发表的数据表明，它们可能更好地被视为假设，而不是既定事实。本综述考虑了与囊虫病免疫相关的一个选定问题，并仔细研究了支持该领域得出的结论的现有证据的性质。所检查的问题是将多头绦虫（Taenia crassiceps）用作由猪带绦虫（Taenia solium）引起的猪囊尾蚴病的模型，以及基于该模型开发的 S3Pvac 疫苗。有强有力的证据支持这样的结论，即已确定的多头绦虫抗原可以限制 ORF 株多头绦虫在小鼠中的腹腔内增殖；然而，这些抗原对猪带绦虫感染的潜在影响需要进一步证实。
