Sciutto Edda, Rosas Gabriela, Hernández Marisela, Morales Julio, Cruz-Revilla Carmen, Toledo Andrea, Manoutcharian Karen, Gevorkian Goar, Blancas Abel, Acero Gonzalo, Hernández Beatriz, Cervantes Jacquelynne, Bobes Raul J, Goldbaum Fernando A, Huerta Mirna, Diaz-Orea Alicia, Fleury Agnes, de Aluja Aline S, Cabrera-Ponce Jose Luis, Herrera-Estrella Luis, Fragoso Gladis, Larralde Carlos
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico.
Vaccine. 2007 Feb 9;25(8):1368-78. doi: 10.1016/j.vaccine.2006.10.018. Epub 2006 Oct 23.
Vaccination of pigs may curtail Taenia solium transmission by reducing the number of cysticerci, the precursors of adult intestinal tapeworms in humans. Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac) has been tested and proved effective in the field against naturally acquired disease. Besides improving of the vaccine's effectiveness, significant reductions in production costs and in the logistics of its administration are necessary for the feasibility of nationwide control programs. This review highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.
给猪接种疫苗可能会通过减少囊尾蚴的数量来减少猪带绦虫的传播，囊尾蚴是人类肠道成虫绦虫的前体。几种抗原制剂在实验环境中可诱导对猪囊尾蚴病的保护作用，但只有一种亚单位疫苗（S3Pvac）经过测试并在实地证明对自然获得性疾病有效。除了提高疫苗的有效性外，大幅降低生产成本及其给药后勤保障对于全国性控制计划的可行性而言也是必要的。本综述重点介绍了S3Pvac的几个版本的研发情况，旨在通过新型递送系统和替代给药途径提高有效性、降低成本并增加可行性。
