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抗猪带绦虫囊尾蚴病的S3Pvac疫苗的研发:历史回顾

Development of the S3Pvac vaccine against porcine Taenia solium cysticercosis: a historical review.

作者信息

Sciutto Edda, Fragoso Gladis, Hernández Marisela, Rosas Gabriela, Martínez José J, Fleury Agnès, Cervantes Jacquelynne, Aluja Aline, Larralde Carlos

机构信息

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF, México.

出版信息

J Parasitol. 2013 Aug;99(4):686-92. doi: 10.1645/GE-3102.1. Epub 2013 Feb 27.

DOI:10.1645/GE-3102.1
PMID:23445359
Abstract

Herein we present a review of our research dealing with vaccination against experimental and naturally acquired porcine Taenia solium cysticercosis using Taenia crassiceps-derived antigens. Results strongly support that the different versions of S3Pvac vaccine are indeed effective against porcine T. solium cysticercosis. Immunological results related to vaccination prove that protection is at least partially mediated by specific immunity. The data also support the validity of T. crassiceps murine cysticercosis as an effective tool to identify vaccine candidates against some metacestode infections.

摘要

在此,我们对使用粗头带绦虫衍生抗原针对实验性和自然获得性猪带绦虫囊尾蚴病进行疫苗接种的研究进行综述。结果有力地支持了不同版本的S3Pvac疫苗确实对猪带绦虫囊尾蚴病有效。与疫苗接种相关的免疫学结果证明,保护作用至少部分是由特异性免疫介导的。这些数据还支持粗头带绦虫小鼠囊尾蚴病作为一种有效工具来鉴定针对某些中绦期感染的候选疫苗的有效性。

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