Uehara Ritei, Yashiro Mayumi, Nakamura Yosikazu, Yanagawa Hiroshi
Department of Public Health, Jichi Medical University, Tochigi, Japan.
Pediatr Int. 2011 Aug;53(4):511-4. doi: 10.1111/j.1442-200X.2010.03267.x.
The aim of this study was to describe time trends of prevalence and detailed characteristics of parents with a history of Kawasaki disease (KD) who had a child with the same disease using data from Japanese nationwide surveys on KD.
Parents with a history of KD were identified using nationwide surveys of KD patients who visited hospitals between 1999 and 2008. To confirm KD histories, a parental questionnaire was sent to pediatricians who reported parental cases to the surveys for KD patients who visited hospitals from 2001 through 2004. Parental history was ascertained by merging data from the parental questionnaire with data from previous nationwide surveys, and detailed information about childhood KD was obtained from survey reports.
During the 10-year study period, 407 parents with a child with KD were reported as having a KD history (0.43%). The prevalence of such parents significantly increased during this study period (regression coefficient: 0.13, 95% confidence interval: 0.05-0.20). Thirty-one confirmed parents with the history were diagnosed between 1966 and 1984. All parents met the case definition of KD, and 33% had been treated with steroids. No parent with a KD history received intravenous immunoglobulin (IVIG).
The prevalence of parents with KD history with a child with the same disease increased during the study period. Some of these parents had not been treated with IVIG because they were diagnosed before its use was widespread in Japan. An increase in the number of parents with the history is expected, thus continuous monitoring of familial cases with KD is required.
本研究旨在利用日本全国川崎病（KD）调查数据，描述有KD病史且其子女也患同病的父母的患病率时间趋势及详细特征。
通过对1999年至2008年期间到医院就诊的KD患者进行全国性调查，确定有KD病史的父母。为确认KD病史，向在2001年至2004年期间到医院就诊的KD患者调查中报告父母病例的儿科医生发送了一份家长问卷。通过将家长问卷数据与之前全国性调查的数据合并来确定家长病史，并从调查报告中获取有关儿童KD的详细信息。
在10年研究期间，报告有407名有KD患儿的父母有KD病史（0.43%）。在此研究期间，这类父母的患病率显著增加（回归系数：0.13，95%置信区间：0.05 - 0.20）。31名确诊有该病史的父母在1966年至1984年期间被诊断。所有父母均符合KD病例定义，33%曾接受类固醇治疗。没有有KD病史的父母接受过静脉注射免疫球蛋白（IVIG）治疗。
在研究期间，有KD病史且其子女也患同病的父母的患病率有所增加。其中一些父母未接受IVIG治疗是因为他们在日本IVIG广泛使用之前就被诊断了。预计有该病史的父母数量会增加，因此需要持续监测KD家族病例。
