Department of Maternal Fetal Medicine, BC Women's Hospital, Vancouver, BC, Canada.
BJOG. 2010 Dec;117(13):1593-8. doi: 10.1111/j.1471-0528.2010.02742.x. Epub 2010 Oct 13.
To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes.
Prospective cohort study.
Vancouver, British Columbia, Canada (49°N).
Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia (n = 221).
Serum 25OHD concentration measured between 10 and 20 weeks of gestation.
Pre-eclampsia and composite adverse pregnancy outcomes.
Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.
Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.
在一组孕妇中确定基于血清 25-羟维生素 D（25OHD）浓度的维生素 D 状态是否与子痫前期或不良妊娠结局的后续风险相关。
前瞻性队列研究。
加拿大不列颠哥伦比亚省温哥华（北纬 49°）。
因子痫前期的临床或生化危险因素而就诊于专科产前诊所的妇女（n=221）。
在妊娠 10 至 20 周之间测量血清 25OHD 浓度。
子痫前期和复合不良妊娠结局。
在这些妇女中，78%的人维生素 D 不足（25OHD<75nmol/L），53%的人维生素 D 缺乏（25OHD<50nmol/L）。25OHD 浓度与子痫前期、妊娠期高血压、早产或复合不良妊娠结局的发生率无差异。
在一组子痫前期高危妇女中，维生素 D 缺乏和不足很常见；然而，它与随后的不良妊娠结局风险无关。
