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AS-30 D腹水肝癌细胞中缺乏活性胆汁酸转运。

The lack of active bile acid transport in AS-30 D ascites hepatoma cells.

作者信息

Kroker R, Anwer M S, Hegner D

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):299-301. doi: 10.1007/BF00498058.

Abstract

The uptake of cholic acid as well as taurocholic acid into AS-30 D ascites hepatoma cells showed linearity with respect to incubation concentrations. It has been suggested that these processes can be described as simple diffusion. In further experiments it could be shown that ascites hepatoma cells were unable to conjugate cholic acid. These results may have significance in the phalloidin action on hepatocytes.

摘要

胆酸以及牛磺胆酸进入AS-30 D腹水肝癌细胞的摄取量与孵育浓度呈线性关系。有人提出这些过程可被描述为简单扩散。在进一步的实验中可以表明,腹水肝癌细胞无法使胆酸结合。这些结果可能在鬼笔环肽对肝细胞的作用方面具有重要意义。

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