Center for Regenerative Medicine, Harvard Medical School, Massachusetts General Hospital, CPZN-4256, 185 Cambridge Street, Boston, MA 02114, USA.
Cell Stem Cell. 2010 Nov 5;7(5):559-64. doi: 10.1016/j.stem.2010.10.007.
Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ESCs suggest that, despite their blastocyst origin, human ESCs exist in a primed pluripotent state. Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them.
多能干细胞 (PSCs) 已被分为两种截然不同的状态：一种是原始的、幼稚的 LIF 依赖性状态，由鼠胚胎干细胞 (mESC) 代表，另一种是在鼠和大鼠上胚层干细胞 (EpiSCs) 中观察到的初始 bFGF 依赖性状态。EpiSCs 与人类胚胎干细胞之间存在巨大的相似性，这表明尽管它们起源于囊胚，但人类胚胎干细胞存在于一种初始的多能状态中。最近的研究结果表明，即使在人类细胞中，原始和初始的多能状态也是可以相互转化的，并暗示生长因子介导的 Nanog 表达可能是调节它们之间平衡的一个重要因素。
