Obesity Prevention Program, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA.
Metabolism. 2011 Jul;60(7):982-6. doi: 10.1016/j.metabol.2010.09.008. Epub 2010 Oct 30.
The purpose of this study was to examine the association of short sleep duration among women in the first year postpartum with inflammation at 3 years postpartum. We studied 479 women in Project Viva, a prospective cohort. At 6 months and 1 year postpartum, women reported the number of hours they slept in a 24-hour period, from which we calculated a weighted average of daily sleep. We used multivariable median regression analyses to predict the independent effects of short sleep duration (≤5 vs >5 h/d) on markers of inflammation, for example, interleukin 6 (IL-6) and C-reactive protein at 3 years postpartum. Women's mean (SD) hours of daily sleep in the first year postpartum was 6.7 (0.96) hours. After adjusting for age, race/ethnicity, education, parity, pre-pregnancy body mass index, excessive gestational weight gain, and gestational age at delivery, we found that postpartum sleep ≤5 h/d was associated with elevated IL-6 (β, 0.25 pg/mL; 95% confidence interval, 0.14-0.43) compared with >5 h/d. Although postpartum sleep ≤5 h/d appeared to also be associated with elevated C-reactive protein (β 0.15 mg/dL; 95% confidence interval, -0.08 to 0.52), these results did not reach statistical significance. Short sleep duration in the first year postpartum is associated with elevated levels of the proinflammatory marker, IL-6, at 3 years postpartum.
本研究旨在探讨产后第一年女性睡眠时长较短与产后 3 年炎症之间的关联。我们研究了 Project Viva 中的 479 名女性，这是一个前瞻性队列。在产后 6 个月和 1 年，女性报告了她们在 24 小时内的睡眠时间，我们从中计算出每日睡眠的加权平均值。我们使用多变量中位数回归分析来预测短睡眠时间（≤5 小时/天与>5 小时/天）对炎症标志物（例如，产后 3 年的白细胞介素 6（IL-6）和 C 反应蛋白）的独立影响。女性在产后第一年的平均（SD）每日睡眠时间为 6.7（0.96）小时。在调整年龄、种族/民族、教育程度、生育次数、孕前体重指数、孕期体重过度增加和分娩时的孕周后，我们发现产后睡眠≤5 小时/天与 IL-6 升高相关（β，0.25 pg/mL；95%置信区间，0.14-0.43），与>5 小时/天相比。尽管产后睡眠≤5 小时/天似乎也与 C 反应蛋白升高相关（β 0.15 mg/dL；95%置信区间，-0.08 至 0.52），但这些结果未达到统计学意义。产后第一年的短睡眠时间与产后 3 年促炎标志物 IL-6 水平升高相关。
