Whitaker Kara M, Marino Regina C, Haapala Jacob L, Foster Laurie, Smith Katy D, Teague April M, Jacobs David R, Fontaine Patricia L, McGovern Patricia M, Schoenfuss Tonya C, Harnack Lisa, Fields David A, Demerath Ellen W
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Obesity (Silver Spring). 2017 Dec;25(12):2092-2099. doi: 10.1002/oby.22025. Epub 2017 Oct 6.
The goal of this study was to examine the associations of maternal weight status before, during, and after pregnancy with breast milk C-reactive protein (CRP) and interleukin 6 (IL-6), two bioactive markers of inflammation, measured at 1 and 3 months post partum.
Participants were 134 exclusively breastfeeding mother-infant dyads taking part in the Mothers and Infants Linked for Health (MILK) study, who provided breast milk samples. Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) were assessed by chart abstraction; postpartum weight loss was measured at the 1- and 3-month study visits. Linear regression was used to examine the associations of maternal weight status with repeated measures of breast milk CRP and IL-6 at 1 and 3 months, after adjustment for potential confounders.
Pre-pregnancy BMI and excessive GWG, but not total GWG or postpartum weight loss, were independently associated with breast milk CRP after adjustment (β = 0.49, P < 0.001 and β = 0.51, P = 0.011, respectively). No associations were observed for IL-6.
High pre-pregnancy BMI and excessive GWG are associated with elevated levels of breast milk CRP. The consequences of infants receiving varying concentrations of breast milk inflammatory markers are unknown; however, it is speculated that there are implications for the intergenerational transmission of disease risk.
本研究的目的是探讨孕期前、孕期中和产后母亲体重状况与产后1个月和3个月测得的母乳中两种炎症生物活性标志物——C反应蛋白（CRP）和白细胞介素6（IL-6）之间的关联。
参与者为134对纯母乳喂养的母婴二元组，他们参与了母婴健康关联研究（MILK），并提供了母乳样本。通过图表摘要评估孕前体重指数（BMI）和孕期体重增加（GWG）；在1个月和3个月的研究访视时测量产后体重减轻情况。在调整潜在混杂因素后，使用线性回归来检验母亲体重状况与产后1个月和3个月母乳CRP和IL-6重复测量值之间的关联。
调整后，孕前BMI和过度GWG与母乳CRP独立相关，但总GWG或产后体重减轻与母乳CRP无关（β分别为0.49，P < 0.001和β为0.51，P = 0.011）。未观察到与IL-6的关联。
孕前BMI高和过度GWG与母乳CRP水平升高有关。婴儿摄入不同浓度母乳炎症标志物的后果尚不清楚；然而，据推测这对疾病风险的代际传递有影响。
