Gözüküçük Murat, Gürsoy Aslı Yarcı, Destegül Emre, Taşkın Salih, Şatıroğlu Hakan
Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey.
Department of Obstetrics and Gynecology, Adana City Hospital, Adana, Turkey.
Gynecol Minim Invasive Ther. 2021 Nov 5;10(4):210-214. doi: 10.4103/GMIT.GMIT_30_20. eCollection 2021 Oct-Dec.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in infertile women characterized by both reproductive and metabolic dysfunctions of different degrees. Furthermore, it has been associated with increased cardiovascular disease (CVD) risk and related long-term health sequela. The aim of this study is to evaluate serum homocysteine (Hcy) and C-reactive protein (CRP) levels in women with PCOS and to evaluate their relationship with clinical and laboratory parameters in women with PCOS.
The prospective single-center study included 45 women with PCOS (study group) and 41 control subjects. Demographic variables and Hcy, CRP, fasting blood glucose, insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, total and free testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone levels, and lipid profiles of the subjects were recorded. homeostatic model assessment for insulin resistance (HOMA-IR) indexes were calculated.
Fasting plasma glucose, insulin, HOMA-IR, free and total testosterone levels, and clinical hirsutism were significantly higher in the study group. There was no statistically significant difference in lipid profile between groups. Hcy and CRP levels were higher in the study group, which was not statistically significantly different ( > 0.05).
Some of the parameters that are correlated with CVD risk were found to be higher in women with PCOS, although the difference for Hcy and CRP did not reach statistical significance. However, the current study reveals that the CVD risk associated with PCOS deserves more comprehensive prospective studies with long-term outcomes.
多囊卵巢综合征（PCOS）是不孕女性中最常见的内分泌疾病，其特征为不同程度的生殖和代谢功能障碍。此外，它还与心血管疾病（CVD）风险增加及相关的长期健康后果有关。本研究的目的是评估PCOS女性的血清同型半胱氨酸（Hcy）和C反应蛋白（CRP）水平，并评估它们与PCOS女性临床和实验室参数的关系。
这项前瞻性单中心研究纳入了45例PCOS女性（研究组）和41例对照受试者。记录了受试者的人口统计学变量以及Hcy、CRP、空腹血糖、胰岛素、促卵泡激素、促黄体生成素、雌二醇、总睾酮和游离睾酮、硫酸脱氢表雄酮、促甲状腺激素水平以及血脂谱。计算了胰岛素抵抗的稳态模型评估（HOMA-IR）指数。
研究组的空腹血糖、胰岛素、HOMA-IR、游离和总睾酮水平以及临床多毛症显著更高。两组之间的血脂谱无统计学显著差异。研究组的Hcy和CRP水平更高，但差异无统计学意义（>0.05）。
尽管Hcy和CRP的差异未达到统计学意义，但发现与CVD风险相关的一些参数在PCOS女性中更高。然而，当前研究表明，与PCOS相关的CVD风险值得进行更全面的、具有长期结果的前瞻性研究。
