Llagostera Español M, Asenjo Vázquez C, Martí i Nogué M, Vernetta Porta M A, Alvarez Funes V, Serrano I
Unidad Docente de Medicina Familiar y Comunitaria, Barcelona.
Aten Primaria. 1990 Nov;7(10):630-3.
We evaluated 31 patients from the ABS La Gavarra in Cornellà de Llobregat who fulfilled the following criteria: they were male, they had mild to moderate chronic limitation to airflow (CLAF), their disease and/or other accompanying conditions were stable, and they were receiving chronic slow release theophylline therapy. We investigated theophylline blood levels in these patients, attempting to correct the doses when appropriate, and we correlated the therapeutic levels with the subjective clinical improvement, which was also assessed by peak flow meter values. A total of 60% of patients had therapeutic levels. After correcting the dose, 64% had therapeutic levels with an increase of spirometric values of 4%. This improvement has small clinical relevance as it does not reach the expected 15%. The results of this study help to reassess the leading role of theophyllines in the therapeutic armamentarium available for CLAF.
我们评估了来自康奈尔拉·德略夫雷加特的ABS拉加瓦拉的31名患者，这些患者符合以下标准：男性，患有轻度至中度慢性气流受限（CLAF），其疾病和/或其他伴随病症稳定，且正在接受慢性缓释茶碱治疗。我们检测了这些患者的茶碱血药浓度，在适当的时候尝试调整剂量，并将治疗浓度与主观临床改善情况相关联，主观临床改善情况也通过峰值流量计数值进行评估。共有60%的患者达到治疗浓度。调整剂量后，64%的患者达到治疗浓度，肺活量测定值增加了4%。这种改善的临床相关性较小，因为未达到预期的15%。本研究结果有助于重新评估茶碱在CLAF可用治疗药物中的主导作用。
