Thompson P J, Kemp M W, McAllister W A, Turner-Warwick M
Br J Dis Chest. 1983 Jul;77(3):293-8.
Eighteen patients with airways obstruction were given slow release theophylline and were then investigated to determine the influence of a standard meal upon the serum levels achieved over the ensuing 12-hour period. After food the peak to trough differences were decreased and the serum levels were significantly lower over the first 6 hours. In this study, the patients were given 10 mg/kg/day of slow release theophylline and none subsequently was found to have toxic levels, therefore this was considered to be a reasonable dose with which to initiate therapy in adults with uncomplicated airflow limitation. However even under the strictly controlled conditions of the study there were wide variations between individuals in the blood levels achieved and serum monitoring is necessary to use theophylline in an optimal fashion.
18名气道阻塞患者服用了缓释茶碱，随后进行研究以确定一顿标准餐对随后12小时内所达到的血清水平的影响。进食后，峰谷差异减小，且在最初6小时内血清水平显著降低。在本研究中，患者服用10mg/kg/天的缓释茶碱，随后未发现有中毒水平，因此这被认为是对无并发症气流受限的成人开始治疗的合理剂量。然而，即使在该研究的严格控制条件下，个体之间所达到的血药水平仍存在很大差异，为了以最佳方式使用茶碱，血清监测是必要的。
