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Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.癌症中替代前体 mRNA 剪接调控：脱节的通路和程序。
Genes Dev. 2010 Nov 1;24(21):2343-64. doi: 10.1101/gad.1973010.
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Misregulation of pre-mRNA alternative splicing in cancer.癌症中前体 mRNA 可变剪接的失调。
Cancer Discov. 2013 Nov;3(11):1228-37. doi: 10.1158/2159-8290.CD-13-0253. Epub 2013 Oct 21.
3
Alternative RNA splicing and cancer.选择性 RNA 剪接与癌症。
Wiley Interdiscip Rev RNA. 2013 Sep-Oct;4(5):547-66. doi: 10.1002/wrna.1178. Epub 2013 Jun 13.
4
Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics.非经典 mRNA 剪接在癌症代谢、免疫反应和治疗中的影响和机制。
Mol Ther. 2022 Mar 2;30(3):1018-1035. doi: 10.1016/j.ymthe.2021.11.010. Epub 2021 Nov 15.
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Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β.SMAD3通过PCBP1对可变剪接的直接调控对于TGF-β的促肿瘤作用至关重要。
Mol Cell. 2016 Nov 3;64(3):549-564. doi: 10.1016/j.molcel.2016.09.013. Epub 2016 Oct 13.
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Hypoxia alters splicing of the cancer associated Fas gene.缺氧改变了与癌症相关的 Fas 基因的剪接。
Exp Cell Res. 2019 Jul 1;380(1):29-35. doi: 10.1016/j.yexcr.2019.04.015. Epub 2019 Apr 17.
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From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.从癌症中的一般异常可变剪接及其治疗应用到致癌性DMTF1异构体的发现
Int J Mol Sci. 2017 Mar 2;18(3):191. doi: 10.3390/ijms18030191.
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The implications of alternative pre-mRNA splicing in cell signal transduction.替代前体 mRNA 剪接在细胞信号转导中的意义。
Exp Mol Med. 2023 Apr;55(4):755-766. doi: 10.1038/s12276-023-00981-7. Epub 2023 Apr 3.
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[Disturbances of alternative splicing in cancer].[癌症中的可变剪接紊乱]
Postepy Biochem. 2011;57(3):257-65.
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Non-coding functions of alternative pre-mRNA splicing in development.可变前体mRNA剪接在发育过程中的非编码功能。
Semin Cell Dev Biol. 2015 Dec;47-48:32-9. doi: 10.1016/j.semcdb.2015.10.018. Epub 2015 Oct 19.
引用本文的文献
1
Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response.PHRF1的PHD结构域对组蛋白H3 N端的识别是正确的DNA损伤反应所必需的。
Nucleic Acids Res. 2025 Jul 8;53(13). doi: 10.1093/nar/gkaf666.
2
Screening and validation of key genes involved in castration-resistant prostate cancer based on transcriptomics sequencing.基于转录组测序的去势抵抗性前列腺癌关键基因的筛选与验证
Sci Rep. 2025 Jul 15;15(1):25648. doi: 10.1038/s41598-025-11397-w.
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The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma.一个RNA结合蛋白组对调节肝细胞癌中RSPO-LGR4/5-ZNRF3/RNF43模块及免疫微环境的影响
BMC Cancer. 2025 Apr 22;25(1):751. doi: 10.1186/s12885-025-13874-x.
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Prognostic implications of alternative splicing events and key splicing factors in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中可变剪接事件和关键剪接因子的预后意义
Discov Oncol. 2025 Mar 31;16(1):430. doi: 10.1007/s12672-025-02214-x.
5
Tumor-promoting effect and tumor immunity of SRSFs.丝氨酸/精氨酸丰富剪接因子（SRSFs）的促肿瘤作用及肿瘤免疫
Front Cell Dev Biol. 2025 Mar 10;13:1527309. doi: 10.3389/fcell.2025.1527309. eCollection 2025.
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Vertical growth of rhenium disulfide on rGO empowers multi-signal amplification for ultrasensitive MiRNA-21 detection.二硫化铼在还原氧化石墨烯上的垂直生长为超灵敏检测微小核糖核酸-21提供了多信号放大功能。
Mikrochim Acta. 2025 Feb 19;192(3):176. doi: 10.1007/s00604-024-06926-9.
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Functions of the Muscleblind-like protein family and their role in disease.肌肉盲样蛋白家族的功能及其在疾病中的作用。
Cell Commun Signal. 2025 Feb 18;23(1):97. doi: 10.1186/s12964-025-02102-5.
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Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer.矛盾基因的发现：重新评估癌症中过表达基因的预后影响。
Front Cell Dev Biol. 2025 Jan 22;13:1525345. doi: 10.3389/fcell.2025.1525345. eCollection 2025.
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Loss of DDX24 inhibits lung cancer progression by stimulating IKBKG splicing-mediated autophagy.DDX24的缺失通过刺激IKBKG剪接介导的自噬来抑制肺癌进展。
Theranostics. 2025 Jan 2;15(5):1879-1895. doi: 10.7150/thno.102425. eCollection 2025.
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NUMB alternative splicing and isoform-specific functions in development and disease.NUMB在发育和疾病中的可变剪接及异构体特异性功能。
J Biol Chem. 2025 Mar;301(3):108215. doi: 10.1016/j.jbc.2025.108215. Epub 2025 Jan 23.
本文引用的文献
1
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.共价组蛋白修饰——在人类癌症中被错误书写、错误解读和错误擦除。
Nat Rev Cancer. 2010 Jul;10(7):457-69. doi: 10.1038/nrc2876.
2
Alternative splice variants, a new class of protein cancer biomarker candidates: findings in pancreatic cancer and breast cancer with systems biology implications.替代剪接变异体，一类新的蛋白质癌症生物标志物候选物：在胰腺癌和乳腺癌中的发现及其对系统生物学的影响。
Dis Markers. 2010;28(4):241-51. doi: 10.3233/DMA-2010-0702.
3
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).富含丝氨酸/精氨酸的蛋白质剪接因子（SR蛋白）的合理命名法。
Genes Dev. 2010 Jun 1;24(11):1073-4. doi: 10.1101/gad.1934910.
4
Tumor metabolism: hnRNP proteins get in on the act.肿瘤代谢：异质性核糖核蛋白（hnRNP）发挥作用。
Cell Cycle. 2010 May 15;9(10):1863-4. doi: 10.4161/cc.9.10.11675.
5
Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene.鉴定 ASF/SF2 为 cyclin D1b 癌基因的关键、等位基因特异性效应子。
Cancer Res. 2010 May 15;70(10):3975-84. doi: 10.1158/0008-5472.CAN-09-3468. Epub 2010 May 11.
6
Deciphering the splicing code.解读剪接码。
Nature. 2010 May 6;465(7294):53-9. doi: 10.1038/nature09000.
7
A splicing-independent function of SF2/ASF in microRNA processing.SF2/ASF 在 miRNA 加工中的剪接非依赖性功能。
Mol Cell. 2010 Apr 9;38(1):67-77. doi: 10.1016/j.molcel.2010.02.021.
8
Translational control in cancer.癌症中的翻译调控。
Nat Rev Cancer. 2010 Apr;10(4):254-66. doi: 10.1038/nrc2824.
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p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.p53 的转录激活涉及假定肿瘤抑制因子 RBM5 的抗增殖活性。
Int J Cancer. 2011 Jan 15;128(2):304-18. doi: 10.1002/ijc.25345. Epub 2010 Mar 22.
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Targeting the HGF/Met signalling pathway in cancer.针对癌症中的 HGF/Met 信号通路。
Eur J Cancer. 2010 May;46(7):1260-70. doi: 10.1016/j.ejca.2010.02.028. Epub 2010 Mar 19.
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