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从宾夕法尼亚州的鲍曼不动杆菌中鉴定出多种 OXA-40 组碳青霉烯酶，包括一种新型变体 OXA-160。

Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania.

机构信息

Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

出版信息

Antimicrob Agents Chemother. 2011 Jan;55(1):429-32. doi: 10.1128/AAC.01155-10. Epub 2010 Nov 1.

DOI:10.1128/AAC.01155-10
PMID:21041501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3019651/
Abstract

Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored bla(OXA-160), bla(OXA-72), and bla(OXA-40), respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of bla(OXA-160) and bla(OXA-40) beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.

摘要

鉴定出三株携带 OXA-40 组碳青霉烯酶基因的鲍曼不动杆菌分离株。它们分别属于新的序列型（ST122、ST123 和 ST124），并分别携带 bla(OXA-160)、bla(OXA-72) 和 bla(OXA-40)。OXA-160 是 OXA-40 的新型变体，其 P227S 取代。产生 OXA-160 的大肠杆菌同源克隆对碳青霉烯类药物的敏感性高于产生 OXA-40 的克隆。bla(OXA-160)和 bla(OXA-40)的遗传环境超出了推定的 XerC/XerD 重组位点，与以前报道的支架不同。

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