新型物种遗传学方法鉴定米氏链球菌属中对肺炎链球菌具有利福平耐药性的供体菌株。
New species genetic approach to identify strains of mitis group streptococci that are donors of rifampin resistance to Streptococcus pneumoniae.
机构信息
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2011 Jan;55(1):368-72. doi: 10.1128/AAC.00856-10. Epub 2010 Nov 1.
Abstract
Eight rifampin-resistant streptococci of the mitis group were identified at the species level by using a concatenated 16S rRNA gene-sodA-rpoB-hlpA sequence. Characterization of their rpoB alleles showed single amino acid changes involved in rifampin resistance. Comparison of RpoB sequences from pneumococcal recombinant isolates, viridans isolates, and type strains revealed a species-specific amino acid signature, which allowed it to be ascertained that recombinant RpoBs were originated in genetic interchanges with Streptococcus mitis and Streptococcus oralis.
摘要
8 株利福平耐药的米氏链球菌通过串联 16S rRNA 基因-sodA-rpoB-hlpA 序列在种水平上得到鉴定。对其 rpoB 等位基因的特征分析表明，涉及利福平耐药的单个氨基酸发生了变化。比较肺炎链球菌重组分离株、草绿色链球菌分离株和标准株的 RpoB 序列，揭示了一种种特异性的氨基酸特征，从而可以确定重组 RpoB 是与米氏链球菌和口腔链球菌发生基因交换而产生的。
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