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耐利福平的缓症链球菌临床分离株中的rpoB基因突变。

rpoB mutations in Streptococcus mitis clinical isolates resistant to rifampin.

作者信息

Achour Wafa, Guenni Olfa, Fines Marguerite, Leclercq Roland, Ben Hassen Assia

机构信息

Laboratoire du Centre National de Greffe de Moelle Osseuse, 1006 Tunis, Tunisia.

出版信息

Antimicrob Agents Chemother. 2004 Jul;48(7):2757-9. doi: 10.1128/AAC.48.7.2757-2759.2004.

DOI:10.1128/AAC.48.7.2757-2759.2004
PMID:15215145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC434179/
Abstract

Activity of rifampin against 129 Streptococcus mitis isolates obtained from patients with hematologic cancer was investigated. One hundred twenty-five strains were susceptible to rifampin, and 4 were resistant (MIC = 32 to 64 microg/ml). Resistance to rifampin was related to mutations in the rpoB gene: His(526)Asn in three strains and His(526)Asp in one strain.

摘要

研究了利福平对129株从血液系统癌症患者中分离出的缓症链球菌的活性。125株菌株对利福平敏感，4株耐药（MIC = 32至64微克/毫升）。对利福平的耐药性与rpoB基因突变有关：三株菌株为His(526)Asn，一株菌株为His(526)Asp。

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本文引用的文献

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J Clin Microbiol. 2003 Jun;41(6):2337-40. doi: 10.1128/JCM.41.6.2337-2340.2003.
2
Low-level resistance to rifampin in Streptococcus pneumoniae.肺炎链球菌对利福平的低水平耐药性。
Antimicrob Agents Chemother. 2003 Mar;47(3):863-8. doi: 10.1128/AAC.47.3.863-868.2003.
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Rifampin resistance in Streptococcus pyogenes.化脓性链球菌对利福平的耐药性。
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Antimicrob Agents Chemother. 2002 May;46(5):1571-3. doi: 10.1128/AAC.46.5.1571-1573.2002.
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Clin Microbiol Infect. 2002 Feb;8(2):65-9. doi: 10.1046/j.1198-743x.2001.00398.x.
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