Department of Nutrition Science-Dietetics, Harokopio University, Athens, Greece.
J Am Coll Nutr. 2010 Aug;29(4):357-64. doi: 10.1080/07315724.2010.10719852.
The aim of this work was to investigate the association between consumption of dairy products and levels of various inflammatory markers among adults with no evidence of cardiovascular or other chronic disease.
The ATTICA study is a cross-sectional survey that enrolled 1514 men (18-87 years old) and 1528 women (18-89 years old) from the Attica region in Greece. Fasting blood samples were collected and dietary habits (including consumption of dairy products [i.e., milk, cheese, and yogurt]) were evaluated using a validated food frequency questionnaire.
We observed that C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels of individuals consuming between 11 and 14 servings of dairy products per week were almost 16%, 5%, and 12% lower, respectively, than in those consuming fewer than 8 servings (p < 0.05), while those consuming more than 14 servings per week had 29%, 9%, and 20% lower levels of CRP, IL-6, and TNF-α, respectively (p < 0.01), even after adjustments were made for age, gender, smoking, physical activity, body mass, dietary habits, and other potential confounders.
We identified an inverse association between dairy products consumption and levels of various inflammatory markers among healthy adults. Additional clinical trials are needed to refute or confirm our findings.
本研究旨在探讨在无心血管或其他慢性疾病证据的成年人中，乳制品消费与各种炎症标志物水平之间的关联。
ATTICA 研究是一项横断面调查，共纳入来自希腊阿提卡地区的 1514 名男性（18-87 岁）和 1528 名女性（18-89 岁）。采集空腹血样，并使用经过验证的食物频率问卷评估饮食习惯（包括乳制品[如牛奶、奶酪和酸奶]的消费）。
我们观察到，每周食用 11-14 份乳制品的个体的 C 反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平分别比每周食用少于 8 份的个体低约 16%、5%和 12%（p<0.05），而每周食用超过 14 份乳制品的个体的 CRP、IL-6 和 TNF-α 水平分别低 29%、9%和 20%（p<0.01），即使在调整了年龄、性别、吸烟、身体活动、体重、饮食习惯和其他潜在混杂因素后也是如此。
我们发现，在健康成年人中，乳制品消费与各种炎症标志物水平之间存在负相关关系。需要进行更多的临床试验来反驳或证实我们的发现。
