Nutrition Department, Public Health School, University of São Paulo, Brazil.
Nutrition Department, Public Health School, University of São Paulo, Brazil.
Nutrition. 2018 Apr;48:1-5. doi: 10.1016/j.nut.2017.10.003. Epub 2017 Oct 26.
The aim of this study was to investigate the association between dairy product consumption and plasma inflammatory biomarkers levels among a representative sample of Brazilian adults from São Paulo City.
Data were acquired from the Health Survey for São Paulo, a cross-sectional population-based study. All individuals 20 to 59 y of age with complete food consumption information (24-h dietary recall and food frequency questionnaire) and blood sample analysis were included (N = 259). The sample was separated into two groups according to systemic inflammatory pattern considering plasma levels of C-reactive protein; tumor necrosis factor-α; soluble intracellular adhesion molecule; soluble vascular cell adhesion molecule, monocyte chemoattractant protein; interleukin-1β, -6, -8, -10, and -12; adiponectin; leptin; and homocysteine. Multiple logistic regression tests were conducted to estimate the odds ratio for the inflammatory cluster across tertiles of dairy consumption.
When adjusted by age, smoking status, and energy intake the odds ratio for the inflammatory cluster group in the highest tertile of yogurt consumption was 0.34 (95% confidence interval [CI], 0.14-0.81) relative to the reference tertile, demonstrating also a linear effect (P = 0.015). Cheese consumption exhibited an odds ratio of 2.49 (95% CI, 1.09-5.75) relative to the reference.
Increasing yogurt consumption might have a protective effect on inflammation, whereas cheese consumption appears to be associated with a proinflammatory status. The results of the present study aggregate a new perspective on existing evidence demonstrating the importance of assessing the contribution of dairy products on diet and their effect on the development of non-communicable diseases and associated risk factors.
本研究旨在调查巴西圣保罗市代表性成年人样本中乳制品消费与血浆炎症生物标志物水平之间的关联。
数据来自圣保罗健康调查，这是一项基于人群的横断面研究。所有年龄在 20 至 59 岁之间、具有完整食物消费信息（24 小时膳食回忆和食物频率问卷）和血液样本分析的个体均被纳入研究（N=259）。根据血浆 C 反应蛋白、肿瘤坏死因子-α、可溶性细胞间黏附分子、可溶性血管细胞黏附分子、单核细胞趋化蛋白、白细胞介素-1β、-6、-8、-10、-12、脂联素、瘦素和同型半胱氨酸水平，将样本分为两组，以考虑全身炎症模式。采用多因素逻辑回归检验来估计乳制品消费三分位组的炎症簇比数比。
在校正年龄、吸烟状况和能量摄入后，与参考三分位组相比，酸奶摄入最高三分位组的炎症簇比数比为 0.34（95%置信区间 [CI]，0.14-0.81），表明存在线性效应（P=0.015）。与参考组相比，奶酪消费的比值比为 2.49（95% CI，1.09-5.75）。
增加酸奶的摄入可能对炎症具有保护作用，而奶酪的摄入似乎与促炎状态有关。本研究的结果提供了一个新的视角，证明了评估乳制品在饮食中的贡献及其对非传染性疾病及其相关危险因素发展的影响的重要性。
