Institute of Dentistry, University of Helsinki, PL 41, Helsinki 00014, Finland.
Nicotine Tob Res. 2010 Dec;12(12):1254-60. doi: 10.1093/ntr/ntq190. Epub 2010 Nov 1.
To investigate the association of smoking with bruxism while controlling for genetic and environmental factors using a co-twin-control design. Especially, the role of nicotine dependence was studied in this context.
The material derives from the Finnish Twin Cohort consisting of 12,502 twin individuals who responded to a questionnaire in 1990 (response rate of 77%). All were born in 1930-1957, the mean age being 44 years. The questionnaire covered 103 multiple choice questions, 7 dealing with tobacco use and 22 with sleep and vigilance matters, including perceived bruxism. In addition, a subsample derived from the Nicotine Addiction Genetics Finland Study containing 445 twin individuals was studied.
In age- and gender-controlled multinomial logistic regression, both monthly and rarely reported bruxism associated with both current cigarette smoking (odds ratio [OR] = 1.74 and 1.64) and former cigarette smoking (OR = 1.64 and 1.47). Weekly bruxism associated with current smoking (OR = 2.85). Current smokers smoking 20 or more cigarettes a day reported weekly bruxism more likely (OR = 1.61-1.97) than those smoking less. Among twin pairs (N = 142) in which one twin was a weekly bruxer and the cotwin a never bruxer, there were 13 monozygotic pairs in which one twin was a current smoker and the other twin was not. In all cases, the bruxer was the smoker (p = .0003). Nicotine dependence associated significantly with bruxism.
Our twin study provides novel evidence for a possible causal link between tobacco use and bruxism among middle-aged adults. Nicotine dependence may be a significant predisposing factor for bruxism.
采用同卵双生子对照设计，在控制遗传和环境因素的情况下，研究吸烟与磨牙症之间的关联。特别是，在这种情况下研究了尼古丁依赖的作用。
本研究资料来源于芬兰双胞胎队列，该队列由 12502 名在 1990 年（应答率为 77%）回答问卷的双胞胎个体组成。所有个体均出生于 1930 年至 1957 年，平均年龄为 44 岁。问卷涵盖了 103 个多项选择题，其中 7 个涉及烟草使用，22 个涉及睡眠和警觉问题，包括感知磨牙症。此外，还研究了来自芬兰尼古丁成瘾遗传学研究的一个包含 445 对双胞胎的子样本。
在年龄和性别控制的多项逻辑回归中，每月和偶尔报告的磨牙症与当前吸烟（优势比[OR] = 1.74 和 1.64）和既往吸烟（OR = 1.64 和 1.47）均相关。每周磨牙症与当前吸烟（OR = 2.85）相关。每天吸烟 20 支或以上的当前吸烟者更有可能报告每周磨牙症（OR = 1.61-1.97），而吸烟较少者则较少报告。在 142 对双胞胎中（其中一对双胞胎中一个是每周磨牙者，另一个是从不磨牙者），有 13 对双胞胎是同卵双胞胎，其中一个双胞胎是当前吸烟者，另一个双胞胎不是。在所有情况下，磨牙者都是吸烟者（p =.0003）。尼古丁依赖与磨牙症显著相关。
我们的双胞胎研究为中年人群中烟草使用与磨牙症之间可能存在因果关系提供了新的证据。尼古丁依赖可能是磨牙症的一个重要易感因素。
