Modica M A, di Lorenzo G, Galluzzo A, Giordano C, Portelli M R, Candore G, Caruso C
Istituto di Patologia generale dell'Università di Palermo, Italy.
Autoimmunity. 1990;7(2-3):87-96. doi: 10.3109/08916939008993381.
Several studies have shown that HLA-B8,DR3 positive subjects may display T cell dysfunctions. Recently, a soluble form of the receptor for IL-2 (sIL-2R) has been demonstrated in human sera and in vitro-stimulated culture supernatant from human T lymphocytes. In the present paper we report sIL-2R serum levels and sIL-2R production from peripheral blood mononuclear cells in HLA-B8,DR3 positive subjects. We found that HLA-B8,DR3 positive subjects have the highest values of serum sIL-2R, but comparing the values of these subjects with those of negative ones no significant difference was observed. As regards the in vitro production of sIL-2R, no difference exists for unstimulated cultures, whereas after stimulation, the HLA-B8,DR3 positive subjects showed the lowest values compared with negative ones. It is noteworthy that these changes are observed in autoimmune diseases linked to this HLA phenotype.
多项研究表明，HLA - B8、DR3阳性个体可能存在T细胞功能障碍。最近，已在人血清以及人T淋巴细胞的体外刺激培养上清液中证实了白细胞介素 - 2受体的可溶性形式（sIL - 2R）。在本文中，我们报告了HLA - B8、DR3阳性个体的血清sIL - 2R水平以及外周血单个核细胞产生sIL - 2R的情况。我们发现，HLA - B8、DR3阳性个体的血清sIL - 2R值最高，但将这些个体的值与阴性个体的值进行比较时，未观察到显著差异。关于sIL - 2R的体外产生，未刺激的培养物中不存在差异，而在刺激后，与阴性个体相比，HLA - B8、DR3阳性个体的值最低。值得注意的是，在与这种HLA表型相关的自身免疫性疾病中观察到了这些变化。
