Caruso C, Di Lorenzo G, Modica M A, Candore G, Portelli M R, Crescimanno G, Ingrassia A, Sangiorgi G B, Salerno A
Istituto di Patologia generale, Universita di Palermo, Italy.
Mech Ageing Dev. 1991 Jun 14;59(1-2):27-35. doi: 10.1016/0047-6374(91)90071-7.
The evidence from several studies indicates that as individuals age, they may display immune dysfunctions, mostly T cell dysfunctions. Recently, a soluble form of the receptor for interleukin-2 (IL-2) (sIL-2R) has been demonstrated in human sera and in vitro stimulated culture supernatants from human T lymphocytes. In the present paper, we report in vitro sIL-2R production from peripheral blood mononuclear cells in elderly subjects. The results show that no difference exists for unstimulated cultures, whereas after mitogen stimulation the elderly subjects showed the lowest values compared with young ones. These findings suggest that sIL-2R may provide a new tool for the study of T lymphocyte dysfunctions in old age.
多项研究的证据表明，随着个体年龄增长，他们可能会出现免疫功能障碍，主要是T细胞功能障碍。最近，在人血清以及来自人T淋巴细胞的体外刺激培养上清液中已证实存在白细胞介素-2（IL-2）受体的可溶性形式（sIL-2R）。在本文中，我们报告了老年受试者外周血单核细胞的体外sIL-2R产生情况。结果显示，未刺激培养时不存在差异，而在有丝分裂原刺激后，老年受试者的值与年轻受试者相比最低。这些发现表明，sIL-2R可能为研究老年期T淋巴细胞功能障碍提供一种新工具。
