Kothari Ruchi, Singh Ramji, Singh Smita, Jain Manish, Bokariya Pradeep, Khatoon Maria
Department of Physiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, India.
J Pediatr Neurosci. 2010 Jan;5(1):12-7. doi: 10.4103/1817-1745.66671.
Cerebral palsy (CP) is a heterogeneous group of permanent, non-progressive motor disorders of movement and posture caused by chronic brain injuries. It is the most common cause of physical disability in childhood; spastic cerebral palsy being the most prevalent of its various forms. There is scanty information about the neurophysiologic investigations in children diagnosed as having spastic CP.
The aim of the study was to investigate the relationship between abnormal VEP and BAEP findings with different clinical parameters in children with spastic cerebral palsy.
Fifteen children with spastic CP in the age range 4 months to 10 years participated in this study. Evaluation of VEPs, brainstem evoked potentials (BAEPs) were performed in all study patients as well as 35 healthy children as controls. The study was conducted after obtaining ethics committee approval and informed consent of parents.
Significance of difference in the mean values of different parameters in different groups was assessed by Student's "t" test and the P value <0.05 was considered to be significant. All the values were expressed as mean ± 1 Std. Deviation.
A significant difference was found in the VEP latencies and amplitude between the subjects with CP and controls. Striking BAEP abnormalities in CP patients include prolongation of absolute latency of wave V, interpeak latencies of III-V and lowered I-V ratio. Abnormal VEPs and BAEPs in children with bilateral spastic cerebral palsy demonstrated a correlation with the presence of moderate to severe developmental delay.
The differences in VEPs and BAEPs were determined between CP children and healthy children. The abnormalities found are probably linked to the neurological deficits present in cases of cerebral palsy.
脑瘫（CP）是一组由慢性脑损伤引起的永久性、非进行性运动和姿势的异质性运动障碍。它是儿童身体残疾的最常见原因；痉挛性脑瘫是其各种形式中最普遍的一种。关于被诊断为痉挛性脑瘫儿童的神经生理学检查的信息很少。
本研究的目的是探讨痉挛性脑瘫患儿异常视觉诱发电位（VEP）和脑干听觉诱发电位（BAEP）结果与不同临床参数之间的关系。
15名年龄在4个月至10岁之间的痉挛性脑瘫患儿参与了本研究。对所有研究患者以及35名健康儿童作为对照进行了VEP和脑干诱发电位（BAEP）评估。该研究在获得伦理委员会批准并征得家长知情同意后进行。
采用学生“t”检验评估不同组不同参数均值差异的显著性，P值<0.05被认为具有显著性。所有值均表示为均值±1标准差。
脑瘫患儿与对照组之间在VEP潜伏期和波幅方面存在显著差异。脑瘫患者明显的BAEP异常包括V波绝对潜伏期延长、III-V峰间潜伏期延长以及I-V比值降低。双侧痉挛性脑瘫患儿的异常VEP和BAEP与中度至重度发育迟缓的存在相关。
确定了脑瘫患儿与健康儿童在VEP和BAEP方面的差异。所发现的异常可能与脑瘫病例中存在的神经功能缺损有关。
