Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran,Vasco de Quiroga, Tlalpan, Mexico.
Arch Pathol Lab Med. 2010 Nov;134(11):1692-6. doi: 10.5858/2009-0697-OAR.1.
Neuroendocrine tumors of the ampulla of Vater constitute a heterogeneous group of neoplasms clinically and morphologically. Because they are rare, little is known about their demographics and biologic behavior.
To analyze the demographics and the 5- and 10-year relative survival rates of 139 patients with carcinoid tumors and high-grade neuroendocrine carcinomas of the ampulla.
Using data from National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program from 1973 to 2006, we analyzed the demographics, morphology, and survival of patients with carcinoids and neuroendocrine carcinomas of the ampulla.
SEER recorded 6081 cases of malignant neoplasms of the ampulla, of which 82 were carcinoid tumors and 57 were high-grade neuroendocrine carcinomas. Of these 57, 42 were neuroendocrine carcinomas, not otherwise specified; 9 were small cell carcinomas; and 6 were large cell neuroendocrine carcinomas. The incidence was higher in men than in women. Patients with carcinoid tumors were younger (mean age, 61.6 years) than those with high-grade neuroendocrine carcinomas (mean age, 67.5 years). Carcinoid tumors were smaller than high-grade neuroendocrine carcinomas. The frequency of lymph node metastasis was 28.5% for carcinoid tumors and 62% for high-grade neuroendocrine carcinomas. The 5- and 10-year relative survival rates of patients with carcinoid tumors were 82% and 71%, respectively. The 5- and 10-year relative survival rate of patients with high-grade neuroendocrine carcinomas was 15.7%.
Carcinoids of the ampulla of Vater are relatively rare. Carcinoids and high-grade neuroendocrine carcinomas of the ampulla are biologically and clinically similar to these tumors arising in other sites. Carcinoids were smaller and metastasized less frequently than high-grade neuroendocrine carcinomas.
壶腹神经内分泌肿瘤在临床上和形态学上是一组异质性的肿瘤。由于它们比较罕见，所以人们对它们的人口统计学和生物学行为知之甚少。
分析 139 例类癌肿瘤和高级别神经内分泌癌患者的人口统计学数据和 5 年及 10 年相对生存率。
利用美国国家癌症研究所监测、流行病学和最终结果（SEER）计划 1973 年至 2006 年的数据，我们分析了类癌肿瘤和壶腹神经内分泌癌患者的人口统计学、形态学和生存率。
SEER 记录了 6081 例壶腹恶性肿瘤病例，其中 82 例为类癌肿瘤，57 例为高级别神经内分泌癌。在这 57 例中，42 例为未特指的神经内分泌癌；9 例为小细胞癌；6 例为大细胞神经内分泌癌。男性的发病率高于女性。类癌肿瘤患者比高级别神经内分泌癌患者年轻（平均年龄 61.6 岁）。类癌肿瘤比高级别神经内分泌癌小。淋巴结转移的频率分别为 28.5%和 62%。类癌肿瘤患者的 5 年和 10 年相对生存率分别为 82%和 71%，高级别神经内分泌癌患者的 5 年和 10 年相对生存率分别为 15.7%。
壶腹类癌较为罕见。壶腹类癌和高级别神经内分泌癌在生物学和临床上与其他部位的这些肿瘤相似。类癌比高级别神经内分泌癌体积小，转移频率低。
