Verkleij Marieke, van de Griendt Erik-Jonas, Kaptein Ad A, van Essen-Zandvliet Liesbeth, Duiverman Eric, Geenen Rinie
European Asthma and Allergy Center, Davos, Switzerland.
J Asthma. 2011 Feb;48(1):18-24. doi: 10.3109/02770903.2010.528497. Epub 2010 Nov 3.
The aim of this study was to quantify behavioral problems in clinically treated children and adolescents with asthma and to examine the association of these problems and quality of life with difficult-to-treat asthma.
Clinical patients with difficult-to-treat asthma (n = 31) and patients with asthma who were not classified as difficult-to-treat asthma (n = 52) completed the Pediatric Asthma Quality of Life Questionnaire [PAQLQ(S)]. Their parents completed the Child Behavior Checklist (CBCL) to assess behavioral problems. Behavioral problem scores were compared to norms of population reference groups and both behavioral problems and quality of life were compared between children and adolescents with and without difficult-to-treat asthma.
Especially internalizing behavioral problems such as being withdrawn/depressed and somatic complaints were more severe in the asthmatic groups compared to the healthy reference groups. The behavioral problems 'somatic complaints' and 'thought problems' as well as a lower quality of life were more severe in children and adolescents with difficult-to-treat asthma than in asthma patients who did not fulfill the criteria of difficult-to-treat asthma.
Behavioral problems and a lower quality of life are suggested to be more pronounced in clinically treated children and adolescents with difficult-to-treat asthma than in asthma patients who are not classified as difficult-to-treat asthma. With respect to practical implications, our data suggest that health-care professionals should - especially in children and adolescents with difficult-to-treat asthma - assess and, if necessary, treat behavioral problems.
本研究旨在量化临床治疗的哮喘儿童和青少年的行为问题，并探讨这些问题及生活质量与难治性哮喘之间的关联。
难治性哮喘临床患者（n = 31）和未被归类为难治性哮喘的哮喘患者（n = 52）完成了儿童哮喘生活质量问卷[PAQLQ(S)]。他们的父母完成了儿童行为量表（CBCL）以评估行为问题。将行为问题得分与总体参照组的标准进行比较，并比较有和没有难治性哮喘的儿童及青少年之间的行为问题和生活质量。
与健康参照组相比，哮喘组中特别是内向性行为问题，如孤僻/抑郁和躯体主诉更为严重。在难治性哮喘的儿童和青少年中，“躯体主诉”和“思维问题”等行为问题以及较低的生活质量比未达到难治性哮喘标准的哮喘患者更为严重。
与未被归类为难治性哮喘的哮喘患者相比，临床治疗的难治性哮喘儿童和青少年的行为问题和较低的生活质量更为明显。就实际影响而言，我们的数据表明，医疗保健专业人员应该——尤其是在难治性哮喘的儿童和青少年中——评估并在必要时治疗行为问题。
