Health Sciences Practice, Exponent Inc, 185 Hansen Court, Suite 100, Wood Dale, IL 60191, USA.
Nutr J. 2010 Nov 2;9:50. doi: 10.1186/1475-2891-9-50.
Over the past decade, several large epidemiologic investigations of meat intake and prostate cancer have been published. Therefore, a meta-analysis of prospective studies was conducted to estimate potential associations between red or processed meat intake and prostate cancer. Fifteen studies of red meat and 11 studies of processed meat were included in the analyses. High vs. low intake and dose-response analyses were conducted using random effects models to generate summary relative risk estimates (SRRE). No association between high vs. low red meat consumption (SRRE = 1.00, 95% CI: 0.96-1.05) or each 100 g increment of red meat (SRRE = 1.00, 95% CI: 0.95-1.05) and total prostate cancer was observed. Similarly, no association with red meat was observed for advanced prostate cancer (SRRE = 1.01, 95% CI: 0.94-1.09). A weakly elevated summary association between processed meat and total prostate cancer was found (SRRE = 1.05, 95% CI: 0.99-1.12), although heterogeneity was present, the association was attenuated in a sub-group analysis of studies that adjusted for multiple potential confounding factors, and publication bias likely affected the summary effect. In conclusion, the results of this meta-analysis are not supportive of an independent positive association between red or processed meat intake and prostate cancer.
在过去的十年中，已经发表了几项关于肉类摄入量和前列腺癌的大型流行病学研究。因此，进行了荟萃分析，以评估摄入红肉或加工肉类与前列腺癌之间的潜在关联。分析中包括 15 项关于红肉的研究和 11 项关于加工肉类的研究。采用随机效应模型进行高 vs. 低摄入量和剂量反应分析，以生成汇总相对风险估计值（SRRE）。高 vs. 低红肉摄入量（SRRE=1.00，95%CI：0.96-1.05）或每 100 克红肉增量（SRRE=1.00，95%CI：0.95-1.05）与总前列腺癌之间没有关联。同样，对于晚期前列腺癌，也没有发现与红肉有关的关联（SRRE=1.01，95%CI：0.94-1.09）。发现加工肉类与总前列腺癌之间存在微弱的汇总关联（SRRE=1.05，95%CI：0.99-1.12），尽管存在异质性，但在调整了多个潜在混杂因素的研究的亚组分析中，该关联减弱，并且可能存在发表偏倚影响了汇总效果。总之，这项荟萃分析的结果不支持红肉或加工肉类摄入与前列腺癌之间存在独立的正相关关系。
