Reibel Jesper, Holmstrup Palle
Afdeling for Oral Medicin, Odontologisk Institut, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, 2200 København N, Denmark.
Ugeskr Laeger. 2010 Nov 1;172(44):3040-2.
Premalignant disorders of the oral mucosa primarily includes oral leukoplakia. The critical problem is to predict future malignant development. Several markers of malignant development have been suggested, however, possibly the most important is a non-homogeneous clinical appearance. There is no evidence that surgical intervention reduces the risk of malignant transformation. Oral cancer is relatively rare, however, easily detectable and preventable; tobacco and alcohol are by far the most important aetiologic factors. Increasing trends in rates of intraoral cancer are seen in many countries.
口腔黏膜的癌前病变主要包括口腔白斑。关键问题是预测未来的恶性发展。已经提出了几种恶性发展的标志物，然而，可能最重要的是临床外观不均匀。没有证据表明手术干预能降低恶变风险。口腔癌相对罕见，但易于检测和预防；烟草和酒精是迄今为止最重要的病因因素。许多国家口腔癌发病率呈上升趋势。
