Yang S X, Li X Y
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Zhongguo Yao Li Xue Bao. 1990 Jul;11(4):355-9.
Methionine-enkephalin (met-enk) 0.1-100 nmol/L significantly enhanced lymphocyte proliferation induced by T cell mitogens. On the other hand, the peptide markedly inhibited splenocyte blastogenesis induced by B cell mitogen lipopolysaccharides (LPS) and sheep red blood cell (SRBC)-driven plaque-forming cell (PFC) formation in vitro. Met-enk alone had no effect on immune responses. However, naloxone 50 nmol/L had also a stimulating effect on Con A-induced splenocyte proliferation. The similar results were also observed in vivo. The results also indicated that the enhancement of T cell function by met-enk was stronger in immunosuppressed mice than in the normal mice.
0.1 - 100纳摩尔/升的甲硫氨酸脑啡肽（甲硫脑啡肽）显著增强了T细胞有丝分裂原诱导的淋巴细胞增殖。另一方面，该肽在体外显著抑制了B细胞有丝分裂原脂多糖（LPS）诱导的脾细胞增殖以及绵羊红细胞（SRBC）驱动的体外空斑形成细胞（PFC）形成。单独的甲硫脑啡肽对免疫反应没有影响。然而，50纳摩尔/升的纳洛酮对刀豆蛋白A诱导的脾细胞增殖也有刺激作用。在体内也观察到了类似的结果。结果还表明，在免疫抑制小鼠中，甲硫脑啡肽对T细胞功能的增强作用比正常小鼠更强。
