伊朗细胞学检查巴氏涂片阴性的健康女性中高危人乳头瘤病毒16型和18型的流行情况
Prevalence of high-risk human papillomavirus types 16 and 18 in healthy women with cytologically negative pap smear in Iran.
作者信息
Safaei Akbar, Khanlari Mahsa, Momtahen Moghdeh, Monabati Ahmad, Robati Minoo, Amooei Sedigheh, Valibeigi Behnaz, Azarpira Negar
机构信息
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):681-5. doi: 10.4103/0377-4929.72030.
BACKGROUND
Because human papillomavirus (HPV) is one of the causal factors in cervical cancer, understanding the epidemiology of this infection is an important step towards developing strategies for prevention.
MATERIALS AND METHODS
We evaluated the prevalence of high-risk human papillomavirus Types 16 and 18 in cervical samples from 402 healthy women with normal Pap smears by testing with type-specific primers in the polymerase chain reaction. Participants were seen at two gynecological clinics affiliated to the Shiraz University of Medical Sciences in Iran.
RESULT
The prevalence of positive HPV findings was 5.5%; high-risk HPV human papillomavirus Type 16 prevalence was 2% and no patient harbored HPV-18. The prevalence of HPV was 4.5% in younger age group and gradually increased to 20% in the 4 th decade.
CONCLUSION
The prevalence of high-risk HPV was highest in the youngest women and gradually decreased with age. Overall, the prevalence of HPV in our population is low.
背景
由于人乳头瘤病毒（HPV）是宫颈癌的致病因素之一，了解这种感染的流行病学是制定预防策略的重要一步。
材料与方法
我们通过聚合酶链反应中使用型特异性引物检测，评估了402名巴氏涂片正常的健康女性宫颈样本中高危人乳头瘤病毒16型和18型的流行情况。参与者来自伊朗设拉子医科大学附属的两家妇科诊所。
结果
HPV检测阳性率为5.5%；高危人乳头瘤病毒16型流行率为2%，且无患者携带HPV-18型。较年轻年龄组的HPV流行率为4.5%，在第四个十年逐渐增至20%。
结论
高危HPV流行率在最年轻女性中最高，并随年龄增长逐渐下降。总体而言，我们研究人群中的HPV流行率较低。
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