Sohrabi Amir, Hajia Masoud
Dept. of Molecular Biology, Research Center of Health Reference Laboratory, Ministry of Health and Medical Education, Tehran, Iran.
Iran J Pathol. 2017 Winter;12(1):35-44. Epub 2017 Jan 27.
The accuracy of diagnostic assays in Human Papillomavirus (HPV) genital infection and cervical cancer has remained a clinical challenge in diagnosis. Evidence indicates that a large proportion of cervical cancer can be prevented through organized care for HPV and testing. Countries with low per capita income, such as Iran and its neighbours, have no national organized program for cervical cancer screening and vaccination. The aim of this study was to review recent published papers in this region for evaluating the efficacy of released data regarding HPV genotyping system in genital infections and cervical cancer.
Investigating various medical search engines retrieved 46 reports, mostly after 2010, consisting of either home brew protocols or commercial technologies in this field.
Summarized results demonstrated that except a few cases, all reports were limited studies performed in confined populations focusing on attending patients at clinics for regular checkups. In the present study, 52.8% of papers were from Iran and the rest belonged to other countries. The rate of HPV infection was reported in the range of 0.62% to 25% in the normal population, while it varied from 18.75% to 100% in females with cervical cancer. In HPV genotyping surveys, only 26.1 % (12/46) of reports had validated and World Health Organization (WHO) proficient procedures. Also, multiple infections were not mentioned in 56.52% (25/46) of researches.
Employing reliable genotyping methods is the best way for regular screening of cervical cancer related to HPV and precancerous diseases in females of these areas. The focus of most surveys was to come up with the best national policies for establishing a preventive program in Iran and Persian Gulf area.
人乳头瘤病毒（HPV）生殖器感染和宫颈癌诊断检测的准确性一直是临床诊断中的一项挑战。有证据表明，通过对HPV进行有组织的护理和检测，很大一部分宫颈癌是可以预防的。人均收入较低的国家，如伊朗及其邻国，没有全国性的宫颈癌筛查和疫苗接种组织计划。本研究的目的是回顾该地区最近发表的论文，以评估所公布的关于HPV基因分型系统在生殖器感染和宫颈癌方面数据的有效性。
通过调查各种医学搜索引擎检索到46份报告，大多是2010年以后的，内容包括该领域的自制方案或商业技术。
总结结果表明，除少数情况外，所有报告都是在有限人群中进行的有限研究，重点是在诊所接受定期检查的患者。在本研究中，52.8%的论文来自伊朗，其余来自其他国家。正常人群中HPV感染率报告在0.62%至25%之间，而宫颈癌女性的感染率在18.75%至100%之间。在HPV基因分型调查中，只有26.1%（12/46）的报告采用了经过验证的、世界卫生组织（WHO）认可的程序。此外，56.52%（25/46）的研究未提及多重感染情况。
采用可靠的基因分型方法是定期筛查这些地区女性HPV相关宫颈癌及癌前疾病的最佳途径。大多数调查的重点是提出最佳国家政策，以便在伊朗和波斯湾地区建立预防计划。
