Institute of Cognitive Neurology (INECO), Favaloro University, Castex 3293 (1425), Buenos Aires, Argentina.
Nat Rev Neurol. 2010 Nov;6(11):611-23. doi: 10.1038/nrneurol.2010.148. Epub 2010 Oct 12.
A large proportion of human social neuroscience research has focused on the issue of decision-making. Impaired decision-making is a symptomatic feature of a number of neurodegenerative diseases, but the nature of these decision-making deficits depends on the particular disease. Thus, examining the qualitative differences in decision-making impairments associated with different neurodegenerative diseases could provide valuable information regarding the underlying neural basis of decision-making. Nevertheless, few comparative reports of decision-making across patient groups exist. In this Review, we examine the neuroanatomical substrates of decision-making in relation to the neuropathological changes that occur in Alzheimer disease, frontotemporal dementia, Parkinson disease and Huntington disease. We then examine the main findings from studies of decision-making in these neurodegenerative diseases. Finally, we suggest a number of recommendations that future studies could adopt to aid our understanding of decision-making cognition.
很大一部分人类社会神经科学研究都集中在决策问题上。决策障碍是许多神经退行性疾病的一个症状特征，但这些决策缺陷的性质取决于特定的疾病。因此，研究与不同神经退行性疾病相关的决策障碍的定性差异，可以为决策的潜在神经基础提供有价值的信息。然而，针对不同患者群体的决策比较报告很少。在这篇综述中，我们研究了与阿尔茨海默病、额颞叶痴呆、帕金森病和亨廷顿病中发生的神经病理学变化相关的决策的神经解剖学基础。然后，我们研究了这些神经退行性疾病中决策研究的主要发现。最后，我们提出了一些未来研究可以采用的建议，以帮助我们理解决策认知。
