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HER2神经蛋白异质性的临床重要性。

The Clinical Importance of the Heterogeneity of HER2 neu.

作者信息

Davila Enrique, Amazon Kip

机构信息

Aventura Comprehensive Cancer Center, Aventura, Fla., USA.

出版信息

Case Rep Oncol. 2010 Jul 24;3(2):268-271. doi: 10.1159/000319020.

DOI:10.1159/000319020
PMID:21045934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968767/
Abstract

We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend retesting a large portion of the tumor in all cases of initially negative test results.

摘要

我们报告了一名乳腺癌患者，其肿瘤区域通过免疫组织化学检测，HER2 neu呈3+阳性和阴性，二者相邻。根据检测区域的不同，结果完全不同。其临床意义重大。我们建议对所有初始检测结果为阴性的病例重新检测肿瘤的大部分区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dee/2968767/b61fe709129e/cro0003-0268-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dee/2968767/7190cd3c5ad4/cro0003-0268-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dee/2968767/b61fe709129e/cro0003-0268-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dee/2968767/7190cd3c5ad4/cro0003-0268-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dee/2968767/b61fe709129e/cro0003-0268-f02.jpg

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本文引用的文献

1
Genetic heterogeneity in HER2 testing in breast cancer: panel summary and guidelines.乳腺癌HER2检测中的基因异质性：专家组总结与指南
Arch Pathol Lab Med. 2009 Apr;133(4):611-2. doi: 10.5858/133.4.611.
2
Trastuzumab--mechanism of action and use in clinical practice.曲妥珠单抗——作用机制及临床应用
N Engl J Med. 2007 Jul 5;357(1):39-51. doi: 10.1056/NEJMra043186.
3
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer.
评估局部判定为HER2阴性的乳腺癌女性患者中，局部与中心HER2检测结果的不一致率。
Cancer. 2014 Sep 1;120(17):2657-64. doi: 10.1002/cncr.28710. Epub 2014 Jun 13.
4
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry.利用质谱流式细胞术实现亚细胞分辨率的肿瘤组织高多重成像。
Nat Methods. 2014 Apr;11(4):417-22. doi: 10.1038/nmeth.2869. Epub 2014 Mar 2.
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Tumour heterogeneity and immune-modulation.肿瘤异质性与免疫调节。
Curr Opin Pharmacol. 2013 Aug;13(4):497-503. doi: 10.1016/j.coph.2013.04.006. Epub 2013 May 7.
美国临床肿瘤学会/美国病理学家学会关于乳腺癌中人表皮生长因子受体2检测的指南建议
J Clin Oncol. 2007 Jan 1;25(1):118-45. doi: 10.1200/JCO.2006.09.2775. Epub 2006 Dec 11.
4
HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial.由北中部癌症治疗组N9831组间辅助试验标本的当地、中心和参考实验室进行的HER2检测。
J Clin Oncol. 2006 Jul 1;24(19):3032-8. doi: 10.1200/JCO.2005.03.4744.
5
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.基因表达与化疗对淋巴结阴性、雌激素受体阳性乳腺癌女性患者的益处。
J Clin Oncol. 2006 Aug 10;24(23):3726-34. doi: 10.1200/JCO.2005.04.7985. Epub 2006 May 23.
6
Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining.对HER-2免疫染色为可疑(2+)的乳腺癌瘤内异质性及扩增状态的分析
Am J Clin Pathol. 2005 Aug;124(2):273-81. doi: 10.1309/J9VX-ABUG-KC4Y-07DL.
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Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study.曲妥珠单抗和紫杉醇术前治疗后序贯阿霉素/环磷酰胺辅助治疗HER2过表达的II期或III期乳腺癌：一项初步研究。
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