Department of Radiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, 100037, Beijing, China.
Int J Cardiovasc Imaging. 2011 Oct;27(7):979-87. doi: 10.1007/s10554-010-9741-x. Epub 2010 Nov 3.
To analyze cardiac magnetic resonance imaging (CMR) characteristics in patients with isolated left ventricular noncompaction (IVNC) and assess its value in the diagnosis of IVNC in a Chinese adult Han population. We collected a consecutive series of 30 patients with IVNC from January 1, 2007, to December 31, 2008. During the same period, we prospectively included patients drawn from groups given a potential differential diagnosis for IVNC. All magnetic resonance images were analyzed using 17-segment model. Left ventricular ejection fraction was significantly lower for patients with DCM (16.2 ± 5.2%, P < 0.001) and higher in AR (47.6 ± 16.2%, P = 0.009), AS (54.6 ± 21.1%, P = 0.001) and HHD (62.4 ± 6.8%, P < 0.001) compared with IVNC (33.0 ± 14.1%). The two-layered structure was most frequently seen at the apical segments, followed by the mid-cavity and basal segments in patients with INVC. The anterior and lateral walls were more commonly involved in patients with IVNC. The number of noncompacted segments and end-diastolic ratio of non-compacted to compacted myocardium (NC/C ratio) was greater in patients with IVNC than in other five groups. The end-diastolic NC/C ratio of >2.5 had 96.4% sensitivity and 97.4% specificity for identifying patients with IVNC. CMR provides an accurate and reliable evaluation of the localization and extent of noncompacted myocardium at end-diastole. The end-diastolic NC/C ratio of >2.5 had high diagnostic accuracy for IVNC in a Chinese adult Han population.
分析孤立性左心室心肌致密化不全（IVNC）患者的心脏磁共振成像（CMR）特征，并评估其在中国成年汉族人群中诊断 IVNC 的价值。方法：我们连续收集了 2007 年 1 月 1 日至 2008 年 12 月 31 日期间 30 例 IVNC 患者。同期，我们前瞻性纳入了疑似 IVNC 的患者。所有磁共振图像均采用 17 节段模型进行分析。结果：DCM 患者的左心室射血分数明显降低（16.2±5.2%，P<0.001），而 AR（47.6±16.2%，P=0.009）、AS（54.6±21.1%，P=0.001）和 HHD（62.4±6.8%，P<0.001）患者的左心室射血分数明显升高。与 IVNC 患者（33.0±14.1%）相比，IVNC 患者的双层结构最常见于心尖段，其次是中段和基底段。IVNC 患者前壁和侧壁更常受累。IVNC 患者的非致密化节段数和舒张末期非致密化心肌与致密化心肌的比值（NC/C 比值）大于其他五组。舒张末期 NC/C 比值>2.5 对诊断 IVNC 的敏感性为 96.4%，特异性为 97.4%。结论：CMR 可准确、可靠地评估舒张末期非致密化心肌的定位和范围。舒张末期 NC/C 比值>2.5 对中国成年汉族人群 IVNC 的诊断具有较高的准确性。
