Srivastava Arvind K, Maurya Rakesh
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
Indian J Exp Biol. 2010 Mar;48(3):294-8.
Eleven antidiabetic Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. Antidiabetic principles from five plants were isolated. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with standard drug metformin. Some compounds were also screened in db/db mice. Two compounds (PP-1 and PP-2) inhibited significantly the activity of PTPase-1B in an in vitro system. This might be the underlying mechanism of antihyperglycemic activity of these compounds.
在链脲佐菌素诱导的糖尿病大鼠模型中对11种印度抗糖尿病药用植物进行了研究，并提供了科学验证以证明它们的降血糖活性。从5种植物中分离出抗糖尿病成分。对所有分离出的化合物在链脲佐菌素诱导的糖尿病大鼠模型中进行降血糖活性评估，并将活性与标准药物二甲双胍进行比较。还在db/db小鼠中对一些化合物进行了筛选。两种化合物（PP-1和PP-2）在体外系统中显著抑制了蛋白酪氨酸磷酸酶-1B（PTPase-1B）的活性。这可能是这些化合物降血糖活性的潜在机制。
