Department of Cardiology and Pulmonology, Georg August University of Göttingen, Germany.
Clin Chest Med. 2010 Dec;31(4):759-69. doi: 10.1016/j.ccm.2010.06.007. Epub 2010 Aug 12.
Acute venous thromboembolism remains a frequent disease, with an incidence ranging between 23 and 69 cases per 100,000 population per year. Of these patients, approximately one-third present with clinical symptoms of acute pulmonary embolism (PE) and two-thirds with deep venous thrombosis (DVT). Recent registries and cohort studies suggest that approximately 10% of all patients with acute PE die during the first 1 to 3 months after diagnosis. Overall, 1% of all patients admitted to hospitals die of acute PE, and 10% of all hospital deaths are PE-related. These facts emphasize the need to better implement our knowledge on the pathophysiology of the disease, recognize the determinants of death or major adverse events in the early phase of acute PE, and most importantly, identify those patients who necessitate prompt medical, surgical, or interventional treatment to restore the patency of the pulmonary vasculature.
急性静脉血栓栓塞症仍然是一种常见疾病，其发病率为每年每 10 万人中有 23 至 69 例。这些患者中，约三分之一出现急性肺栓塞（PE）的临床症状，三分之二出现深静脉血栓形成（DVT）。最近的登记和队列研究表明，约 10%的所有急性 PE 患者在诊断后 1 至 3 个月内死亡。总体而言，所有因急性 PE 住院的患者中有 1%死亡，所有医院死亡中有 10%与 PE 相关。这些事实强调了需要更好地实施我们对疾病病理生理学的认识，识别急性 PE 早期死亡或主要不良事件的决定因素，最重要的是，识别那些需要及时进行医疗、手术或介入治疗以恢复肺血管通畅的患者。
