• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Diabetes: Podocytes lose their footing.

作者信息

Rask-Madsen Christian, King George L

出版信息

Nature. 2010 Nov 4;468(7320):42-4. doi: 10.1038/468042a.

DOI:10.1038/468042a
PMID:21048754
Abstract
摘要

相似文献

1
Diabetes: Podocytes lose their footing.糖尿病：足细胞失去立足之地。
Nature. 2010 Nov 4;468(7320):42-4. doi: 10.1038/468042a.
2
Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.降低 VEGF-B 信号可改善肾脏脂毒性并预防糖尿病肾病。
Cell Metab. 2017 Mar 7;25(3):713-726. doi: 10.1016/j.cmet.2017.01.004. Epub 2017 Feb 9.
3
Podocytes as a target of insulin.足细胞作为胰岛素的一个作用靶点。
Curr Diabetes Rev. 2011 Jan;7(1):22-7. doi: 10.2174/157339911794273883.
4
Proteinuria, the podocyte, and insulin resistance.蛋白尿、足细胞与胰岛素抵抗。
N Engl J Med. 2010 Nov 18;363(21):2068-9. doi: 10.1056/NEJMcibr1008395.
5
Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms.前列环素I2受体激动作用通过依赖于nephrin的机制保护β细胞功能并减轻蛋白尿。
Diabetes. 2016 May;65(5):1398-409. doi: 10.2337/db15-0783. Epub 2016 Feb 11.
6
Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.长期暴露于胰岛素会导致小鼠和人足细胞胰岛素受体通过溶酶体和蛋白酶体降解而产生胰岛素抵抗。
Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29.
7
Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria.胰岛素信号通路改变在足细胞功能障碍和微量白蛋白尿发病机制中的作用。
Curr Opin Nephrol Hypertens. 2009 Nov;18(6):539-45. doi: 10.1097/MNH.0b013e32832f7002.
8
Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.GIPRdn转基因小鼠的糖尿病性肾脏病变：足细胞肥大和肾小球基底膜增厚先于肾小球肥大和肾小球硬化。
Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. doi: 10.1152/ajprenal.90665.2008. Epub 2009 Feb 11.
9
Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes.高血糖诱导的 SHP-1 表达可阻止足细胞中的胰岛素作用。
Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1188-98. doi: 10.1152/ajpendo.00560.2012. Epub 2013 Mar 26.
10
Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.葡萄糖诱导的活性氧会导致足细胞凋亡以及糖尿病肾病发病初期的足细胞耗竭。
Diabetes. 2006 Jan;55(1):225-33.

引用本文的文献

1
Effects of Prothrombin on Podocytopathy and Proteinuria in Glomerular Disease.凝血酶原对肾小球疾病中足细胞病变和蛋白尿的影响。
J Am Soc Nephrol. 2025 Mar 28;36(7):1327-1342. doi: 10.1681/ASN.0000000676.
2
Coptisine inhibits lipid accumulation in high glucose- and palmitic acid-induced HK-2 cells by regulating the AMPK/ACC/CPT-1 signaling pathway.黄连碱通过调节AMPK/ACC/CPT-1信号通路抑制高糖和棕榈酸诱导的HK-2细胞中的脂质积累。
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):5465-5474. doi: 10.1007/s00210-024-03617-3. Epub 2024 Nov 19.
3
Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia.

本文引用的文献

1
Insulin signaling to the glomerular podocyte is critical for normal kidney function.胰岛素信号向肾小球足细胞的传递对于正常的肾脏功能至关重要。
Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015.
2
FOXOs, cancer and regulation of apoptosis.叉头框蛋白O（FOXOs）、癌症与细胞凋亡调控
Oncogene. 2008 Apr 7;27(16):2312-9. doi: 10.1038/onc.2008.24.
3
Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes.胰岛素对健康、肥胖及糖尿病状态下肾脏钠转运和血压的影响。
足细胞中Src 同源磷酸酶 2 的缺乏与高血糖小鼠的肾脏保护作用有关。
Cell Mol Life Sci. 2022 Sep 14;79(10):516. doi: 10.1007/s00018-022-04517-6.
4
Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy.微管相关蛋白 4 磷酸化诱导足细胞上皮-间质转化导致糖尿病肾病蛋白尿。
Cell Commun Signal. 2022 Jul 28;20(1):115. doi: 10.1186/s12964-022-00883-7.
5
VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses.血管内皮生长因子B抗体与白细胞介素-22融合蛋白通过抑制脂质蓄积和炎症反应改善糖尿病肾病。
Acta Pharm Sin B. 2021 Jan;11(1):127-142. doi: 10.1016/j.apsb.2020.07.002. Epub 2020 Jul 13.
6
Alleviation by Mahuang Fuzi and Shenzhuo Decoction in High Glucose-Induced Podocyte Injury by Inhibiting the Activation of Wnt/-Catenin Signaling Pathway, Resulting in Activation of Podocyte Autophagy.麻黄附子渗浊汤通过抑制Wnt/β-连环蛋白信号通路的激活减轻高糖诱导的足细胞损伤，从而激活足细胞自噬。
Evid Based Complement Alternat Med. 2020 Sep 3;2020:7809427. doi: 10.1155/2020/7809427. eCollection 2020.
7
HDAC6-mediated α-tubulin deacetylation suppresses autophagy and enhances motility of podocytes in diabetic nephropathy.HDAC6 介导的 α-微管蛋白去乙酰化抑制糖尿病肾病中足细胞的自噬并增强其运动能力。
J Cell Mol Med. 2020 Oct;24(19):11558-11572. doi: 10.1111/jcmm.15772. Epub 2020 Sep 4.
8
Thymol alleviates AGEs-induced podocyte injury by a pleiotropic effect via NF-κB-mediated by RhoA/ROCK signalling pathway.麝香草酚通过 NF-κB 介导的 RhoA/ROCK 信号通路的多效作用减轻 AGEs 诱导的足细胞损伤。
Cell Adh Migr. 2020 Dec;14(1):42-56. doi: 10.1080/19336918.2020.1721172.
9
Lipid mediators of insulin signaling in diabetic kidney disease.糖尿病肾病中胰岛素信号的脂质介质。
Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1241-F1252. doi: 10.1152/ajprenal.00379.2019. Epub 2019 Sep 23.
10
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases.Cdc42：胰岛素分泌和糖尿病相关疾病的新型调节剂。
Int J Mol Sci. 2019 Jan 6;20(1):179. doi: 10.3390/ijms20010179.
Am J Physiol Renal Physiol. 2007 Oct;293(4):F974-84. doi: 10.1152/ajprenal.00149.2007. Epub 2007 Aug 8.
4
Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes.疾病机制：胰岛素抵抗和糖尿病中的内皮功能障碍
Nat Clin Pract Endocrinol Metab. 2007 Jan;3(1):46-56. doi: 10.1038/ncpendmet0366.
5
Insulin receptor signals regulating GLUT4 translocation and actin dynamics.调节葡萄糖转运蛋白4易位和肌动蛋白动力学的胰岛素受体信号
Endocr J. 2006 Jun;53(3):267-93. doi: 10.1507/endocrj.kr-65. Epub 2006 May 12.
6
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival.足细胞-内皮细胞间隙中的血管内皮生长因子a信号传导是系膜细胞迁移和存活所必需的。
J Am Soc Nephrol. 2006 Mar;17(3):724-35. doi: 10.1681/ASN.2005080810. Epub 2006 Jan 25.
7
Mouse models of diabetic nephropathy.糖尿病肾病的小鼠模型
J Am Soc Nephrol. 2005 Jan;16(1):27-45. doi: 10.1681/ASN.2004080648. Epub 2004 Nov 24.
8
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.血管内皮生长因子A（VEGF-A）表达的肾小球特异性改变会导致不同的先天性和后天性肾脏疾病。
J Clin Invest. 2003 Mar;111(5):707-16. doi: 10.1172/JCI17423.
9
Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue.
Circulation. 2002 Jan 22;105(3):373-9. doi: 10.1161/hc0302.102143.
10
Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells.胰岛素介导的蛋白激酶Akt刺激：内皮细胞强大的生存信号级联反应。
Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):402-9. doi: 10.1161/01.atv.20.2.402.