琥珀酰化伴刀豆球蛋白A对转化细胞的生长抑制作用。
Growth inhibition of transformed cells with succinylated concanavalin A.
作者信息
Mannino R J, Ballmer K, Burger M M
出版信息
Science. 1978 Sep 1;201(4358):824-6. doi: 10.1126/science.210502.
PMID:210502
Abstract
Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G1 phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.
摘要
琥珀酰化伴刀豆球蛋白A可逆地抑制SV40转化的小鼠3T3细胞的生长，从而导致细胞在细胞周期的G1期积累。在软底物（甲基纤维素）中，琥珀酰化伴刀豆球蛋白A还能使转化细胞恢复未转化细胞典型的生长行为。
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Growth inhibition of transformed cells with succinylated concanavalin A.琥珀酰化伴刀豆球蛋白A对转化细胞的生长抑制作用。
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