Materials Science and Chemical Engineering Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Acta Biomater. 2011 Mar;7(3):921-35. doi: 10.1016/j.actbio.2010.10.030. Epub 2010 Nov 2.
Removal of the natural vitreous body from the eye and its substitution with a tamponade agent may be necessary in cases of complicated retinal detachment. Many materials have been variously proposed and tested over the years in an attempt to find an ideal vitreous substitute. This review highlights the evolution of research in the field of vitreous replacement and chronicles the main advances that have been made in such a context. The suitability and limitations of vitreous tamponade agents and substitutes in current clinical use are examined, and the future promise of experimentally tested biomaterials are described and discussed. Future trends in research are also considered and, specifically, the great potential of polymeric hydrogels is emphasized, as they seem to be very effective in closely mimicking the features of the natural vitreous and they could successfully act as long-term vitreous substitutes without inducing clinical complications in the patient's eye.
在复杂的视网膜脱离病例中，可能需要从眼睛中取出天然玻璃体并用填塞剂替代。多年来，人们已经提出并测试了许多材料，试图寻找一种理想的玻璃体替代品。本综述重点介绍了玻璃体替代领域的研究进展，并记录了在此背景下取得的主要进展。本文还检查了当前临床应用中玻璃体填塞剂和替代品的适用性和局限性，并描述和讨论了经过实验测试的生物材料的未来前景。还考虑了未来的研究趋势，特别是强调了聚合物水凝胶的巨大潜力，因为它们似乎非常有效地模拟天然玻璃体的特征，并且可以作为长期的玻璃体替代品，而不会在患者眼中引起临床并发症。
