Todorović Zoran, Canović Predrag, Gajović Olgica, Mijailović Zeljko
Klinika za infektivne bolesti, Klinicki centar Kragujevac.
Med Pregl. 2010 Mar-Apr;63(3-4):280-4. doi: 10.2298/mpns1004280t.
Hemorrhagic fever with renal syndrome (HFWRS) is an acute infectious disease with abrupt onset, high fever, renal failure and frequent hemorragies. HFWRS during the pregnancy has relatively low occurrence, with only few described cases mostly in the region of the former Soviet Union. Although, according to the data from the literature, the disease is less severe during the pregnancy, the eclampsy, stillbirth and fetal infection were also described.
During the summer period, June-September 2002 in the area of northeast Montenegro, and mainly among people whose job was connected with rural areas, the HFRS was observed more frequently. In that area during the stated period, 12 patients underwent treatment whose disease was confirmed by the IIF method at the Torlak Institute of Virology in Belgrade. Among the patients there were two pregnant women aged 23 and 29 (both in their second pregnancies), in the 23rd and 26th gestational week, respectively. The aim of this study is to present 2 case studies and to show the disease impact on fetal development.
The patients aged 23 and 29 yrs, were previously healthy women in their second pregnancies (23rd and 26th gestational week, respectively). The disease had typical beginning. The predictions made according to the laboratory abnormalities and the level of oliguria were that the disease would have a less severe course. Hemorrraghic syndrome was less prominent, and the laboratory analyses were normalized after 15 to 18 days. The monitoring of pregnancy during the disease period and after recovering showed no fetal suffering. The patients had PV delivery, in 39-th an 40-th, respectively. The newborns blood testing on Hantan viruses was done by ELISA method in Torlak Institute, Belgrade. Only the IgG antibodies (1/512), were detected, the IgM antibodies were not found. Two years later the tests were repeated, and showed negative results.
肾综合征出血热（HFWRS）是一种急性传染病，起病急骤，伴有高热、肾衰竭和频繁出血。妊娠期肾综合征出血热的发病率相对较低，仅有少数病例报道，大多发生在前苏联地区。尽管根据文献资料，该疾病在妊娠期病情较轻，但也有子痫、死产和胎儿感染的报道。
2002年6月至9月夏季期间，在黑山东北部地区，主要是在与农村地区有关联工作的人群中，肾综合征出血热的观察更为频繁。在所述期间，该地区有12名患者接受治疗，其疾病经贝尔格莱德托拉克病毒学研究所的间接免疫荧光法（IIF）确诊。患者中有两名孕妇，年龄分别为23岁和29岁（均为第二次怀孕），分别处于妊娠第23周和第26周。本研究的目的是呈现2例病例研究，并展示该疾病对胎儿发育的影响。
年龄分别为23岁和29岁的患者，此前均为健康的第二次怀孕女性（分别处于妊娠第23周和第26周）。疾病起病典型。根据实验室异常情况和少尿程度预测，疾病病程会较轻。出血综合征不那么突出，实验室分析在15至18天后恢复正常。在患病期间及康复后对妊娠情况进行监测，未发现胎儿有不良情况。患者分别在第39周和第40周进行了剖宫产。在贝尔格莱德托拉克研究所采用酶联免疫吸附测定法（ELISA）对新生儿进行汉坦病毒血液检测。仅检测到IgG抗体（1/512），未发现IgM抗体。两年后重复检测，结果为阴性。
