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利用实验设计优化两种青霉属真菌产生新次级代谢产物。

Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species.

机构信息

Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.

出版信息

J Nat Prod. 2010 Nov 29;73(11):1821-32. doi: 10.1021/np100470h. Epub 2010 Nov 5.

DOI:10.1021/np100470h
PMID:21053938
Abstract

A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites.

摘要

采用分因子设计方法来提高两种青霉菌株的次生代谢产物的产量。该方法最初用于提高生物活性提取物的整体产量，随后用于优化特定生物活性代谢产物的产量。对于草酸青霉和桔青霉，次生代谢产物的产量均提高了 500%以上。从优化生产少量代谢产物的桔青霉培养物中分离并鉴定出两种新的生物碱，桔青霉素 A（5）和 B（6）。

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