Lončar Božana, Stipetić Marinka Mravak, Baričević Marinka, Risović Dubravko
Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Photomed Laser Surg. 2011 Mar;29(3):171-5. doi: 10.1089/pho.2010.2792. Epub 2010 Nov 6.
The aim of this study was to investigate the effect of low-level laser irradiation on the secretory function of salivary glands in 34 patients with xerostomia (dry mouth).
Xerostomia, a common complaint of oral dryness within the elderly population, is caused by a reduction in normal salivary secretion due to different causes. Treatment is aimed at increasing salivary flow, although in most cases it remains palliative.
In this study, laser light from a pulsed Ga-As laser operating at 904 nm was applied bilaterally on each salivary gland area: extraorally on the parotid and submandibular gland areas and intraorally on the sublingual gland area. The operational probe distance from the irradiated area was 0.5 cm resulting in an irradiance of 246 mW/cm(2). The exposure time was 120 sec per daily treatment during 10 consecutive days. The average energy density per exposure was 29.5 J/cm(2). The control group consisted of 16 patients who were treated with 15 mL of a 2% citric acid solution applied as a mouth rinse for 30 sec.
The average difference in the amount of salivation (dQ-sal, mL/min) before and after laser therapy increased linearly from dQ-sal = 0.05 mL/min on the first day, up to dQ-sal = 0.13 mL/min on the last (10th) day of therapy. In the control group, the average dQ-sal initially demonstrated a gradual increase, with a reversal of the trend toward the end of the therapy period and eventually yielding no correlation between the duration of therapy and dQ-sal.
The results of our study indicate that the effects of low-level laser therapy on salivary glands are not only stimulating, but also regenerative to a degree since the glandular response to the same amount of applied laser energy increased linearly over time.
本研究旨在调查低强度激光照射对34例口干症患者唾液腺分泌功能的影响。
口干症是老年人群中常见的口腔干燥主诉，由不同原因导致正常唾液分泌减少引起。治疗旨在增加唾液流量，尽管在大多数情况下仍为姑息性治疗。
在本研究中，使用波长为904nm的脉冲砷化镓激光，双侧照射每个唾液腺区域：腮腺和颌下腺区域采用口外照射，舌下腺区域采用口内照射。操作探头与照射区域的距离为0.5cm，辐照度为246mW/cm²。连续10天，每天治疗的照射时间为120秒。每次照射的平均能量密度为29.5J/cm²。对照组由16例患者组成，他们使用15mL 2%的柠檬酸溶液含漱30秒进行治疗。
激光治疗前后唾液分泌量（dQ-sal，mL/min）的平均差值从治疗第一天的dQ-sal = 0.05mL/min线性增加，至治疗最后一天（第10天）达到dQ-sal = 0.13mL/min。在对照组中，平均dQ-sal最初呈逐渐增加趋势，但在治疗期结束时趋势逆转，最终治疗持续时间与dQ-sal之间无相关性。
我们的研究结果表明，低强度激光治疗对唾液腺的作用不仅具有刺激作用，而且在一定程度上具有再生作用，因为随着时间的推移，腺体对相同剂量激光能量的反应呈线性增加。
