Muir W W, Wagner A E, Buchanan C
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Vet Surg. 1990 Jan-Feb;19(1):83-7. doi: 10.1111/j.1532-950x.1990.tb01146.x.
The effects of increasing respiratory rates on arterial pH, PaCO2, HCO3, and potassium (K) were measured in normal anesthetized dogs. Hyperventilation resulted in increased pH, decreased PaCO2, decreased HCO3, and decreased K compared with those parameters in spontaneously breathing dogs. The changes were related quantitatively: each 10 mmHg decrease in PaCO2 was associated with a pH increase of 0.1, a HCO3 decrease of 2.0 mEq/L, and a K decrease of 0.4 mEq/L. There were no cardiac arrhythmias or clinical signs of hypokalemia. After termination of hyperventilation, serum K was slower to return to control values than PaCO2. The ratio of the duration of hyperventilation to the time required for return of serum K to control was 0.67.
在正常麻醉犬中测量了呼吸频率增加对动脉pH、动脉血二氧化碳分压（PaCO2）、碳酸氢根（HCO3）和钾（K）的影响。与自主呼吸犬相比，过度通气导致pH升高、PaCO2降低、HCO3降低以及K降低。这些变化在数量上是相关的：PaCO2每降低10 mmHg，pH升高0.1，HCO3降低2.0 mEq/L，K降低0.4 mEq/L。未出现心律失常或低钾血症的临床体征。过度通气终止后，血清K恢复到对照值的速度比PaCO2慢。过度通气持续时间与血清K恢复到对照所需时间的比值为0.67。
