Eng. A.B. Growth Factors and Bone Regeneration Research Chair, King Saud University, Riyadh, Saudi Arabia.
Oral Oncol. 2010 Dec;46(12):854-9. doi: 10.1016/j.oraloncology.2010.10.004. Epub 2010 Nov 4.
The overall impression regarding the success of dental implants (DI) in patients having undergone oral cancer therapy remains unclear. The aim of the present review study was to assess the implant survival rate after oral cancer therapy. Databases were explored from 1986 up to and including September 2010 using the following keywords in various combinations: "cancer", "chemotherapy", "dental implant", "oral", "osseointegration", "radiotherapy", "surgery" and "treatment". The eligibility criteria were: (1) original research articles; (2) clinical studies; (3) reference list of pertinent original and review studies; (4) intervention: patients having undergone radio- and chemotherapy following oral cancer surgery; and (5) articles published only in English. Twenty-one clinical studies were included. Results from 16 studies reported that DI can osseointegrate and remain functionally stable in patients having undergone radiotherapy following oral cancer surgery; whereas three studies showed irradiation to have negative effects on the survival of DI. Two studies reported that DI can osseointegrate and remain functionally stable in patients having undergone chemotherapy. It is concluded that DI can osseointegrate and remain functionally stable in patients having undergone oral cancer treatment.
关于接受过口腔癌治疗的患者中牙种植体（DI）成功的总体印象仍不清楚。本综述研究的目的是评估口腔癌治疗后种植体的存活率。从 1986 年到 2010 年 9 月，使用以下关键词的各种组合在数据库中进行了搜索：“癌症”、“化疗”、“牙种植体”、“口腔”、“骨整合”、“放射治疗”、“手术”和“治疗”。入选标准是：（1）原始研究文章；（2）临床研究；（3）相关原始和综述研究的参考文献列表；（4）干预：口腔癌手术后接受放射和化学治疗的患者；（5）仅以英文发表的文章。共纳入 21 项临床研究。16 项研究的结果表明，DI 可以在口腔癌手术后接受放射治疗的患者中实现骨整合并保持功能稳定；而三项研究表明，放射治疗对 DI 的存活率有负面影响。两项研究报告称，DI 可以在接受化疗的患者中实现骨整合并保持功能稳定。结论是，DI 可以在接受口腔癌治疗的患者中实现骨整合并保持功能稳定。
