机械敏感通道：与Piezo蛋白相关
Mechanosensitive channels: in touch with Piezo.
作者信息
Xiao Rui, Xu X Z Shawn
机构信息
Life Sciences Institute and Department of Molecular & Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109, USA.
出版信息
Curr Biol. 2010 Nov 9;20(21):R936-8. doi: 10.1016/j.cub.2010.09.053.
Abstract
Mechanosensory transduction underlies touch, hearing and proprioception and requires mechanosensitive channels that are directly gated by forces; however, the molecular identities of these channels remain largely elusive. A new study has identified Piezo1 and Piezo2 as a novel class of mechanosensitive channels.
摘要
机械感觉转导是触觉、听觉和本体感觉的基础，需要由力直接门控的机械敏感通道；然而，这些通道的分子身份在很大程度上仍然难以捉摸。一项新研究已将Piezo1和Piezo2鉴定为一类新型的机械敏感通道。
相似文献
1
Mechanosensitive channels: in touch with Piezo.机械敏感通道：与Piezo蛋白相关
Curr Biol. 2010 Nov 9;20(21):R936-8. doi: 10.1016/j.cub.2010.09.053.
2
Demystifying Mechanosensitive Piezo Ion Channels.解读机械敏感型Piezo离子通道
Neurosci Bull. 2016 Jun;32(3):307-9. doi: 10.1007/s12264-016-0033-x. Epub 2016 May 11.
3
In Touch With the Mechanosensitive Piezo Channels: Structure, Ion Permeation, and Mechanotransduction.与机械敏感型Piezo通道的联系：结构、离子渗透及机械转导
Curr Top Membr. 2017;79:159-195. doi: 10.1016/bs.ctm.2016.11.006. Epub 2017 Feb 21.
4
The Form and Function of PIEZO2.PIEZO2 的形式和功能。
Annu Rev Biochem. 2021 Jun 20;90:507-534. doi: 10.1146/annurev-biochem-081720-023244.
5
Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.机械激活的压电通道介导小鼠的触摸感知并抑制急性机械性疼痛反应。
Cell Rep. 2019 Feb 5;26(6):1419-1431.e4. doi: 10.1016/j.celrep.2019.01.056.
6
Merkel cells and neurons keep in touch.默克尔细胞与神经元保持联系。
Trends Cell Biol. 2015 Feb;25(2):74-81. doi: 10.1016/j.tcb.2014.10.003. Epub 2014 Dec 2.
7
Mechanosensitive Piezo Channels in the Gastrointestinal Tract.胃肠道中的机械敏感Piezo通道
Curr Top Membr. 2017;79:219-244. doi: 10.1016/bs.ctm.2016.11.003. Epub 2017 Jan 7.
8
The role of PIEZO ion channels in the musculoskeletal system.PIEZO 离子通道在肌肉骨骼系统中的作用。
Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C728-C740. doi: 10.1152/ajpcell.00544.2022. Epub 2023 Jan 30.
9
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!压电机械敏感离子通道：愿原力与你同在！
Rev Physiol Biochem Pharmacol. 2015;169:25-41. doi: 10.1007/112_2015_26.
10
Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.机械敏感离子通道Piezo2对肠嗜铬细胞对机械力的反应很重要。
J Physiol. 2017 Jan 1;595(1):79-91. doi: 10.1113/JP272718. Epub 2016 Aug 13.
引用本文的文献
1
Changes in vascular identity during vascular remodeling.血管重塑过程中血管特性的变化。
JVS Vasc Sci. 2025 Feb 25;6:100282. doi: 10.1016/j.jvssci.2025.100282. eCollection 2025.
2
Influence of the spaceflight environment on macrophage lineages.太空飞行环境对巨噬细胞谱系的影响。
NPJ Microgravity. 2024 Jun 11;10(1):63. doi: 10.1038/s41526-023-00293-0.
3
The role of mechanotransduction in tendon.机械转导在肌腱中的作用。
J Bone Miner Res. 2024 Aug 5;39(7):814-820. doi: 10.1093/jbmr/zjae074.
4
Hydrostatic pressure as a driver of cell and tissue morphogenesis.静水压作为细胞和组织形态发生的驱动力。
Semin Cell Dev Biol. 2022 Nov;131:134-145. doi: 10.1016/j.semcdb.2022.04.021. Epub 2022 May 6.
5
Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells.声动力疗法诱导的氧化应激对钙稳态失衡的作用增强了胶质瘤细胞中的巨噬细胞浸润。
Cancers (Basel). 2022 Apr 18;14(8):2036. doi: 10.3390/cancers14082036.
6
Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis.白血病细胞膜中 Piezo1 的选择性化学激活：单通道分析。
Int J Mol Sci. 2021 Jul 22;22(15):7839. doi: 10.3390/ijms22157839.
7
Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain.Piezo2机械敏感离子通道定位于大鼠外周感觉通路中的感觉神经元和非神经元细胞：对疼痛的影响。
Pain. 2021 Nov 1;162(11):2750-2768. doi: 10.1097/j.pain.0000000000002356.
8
Generators of Pressure-Evoked Currents in Vertebrate Outer Retinal Neurons.脊椎动物外视网膜神经元中产生压力诱发电流的发生器。
Cells. 2021 May 22;10(6):1288. doi: 10.3390/cells10061288.
9
Mechanical Stress Induces Ca-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis.机械应力诱导红细胞内钙依赖信号转导并调节红细胞生成。
Int J Mol Sci. 2021 Jan 19;22(2):955. doi: 10.3390/ijms22020955.
10
Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and Ca Homeostasis.环磷酸腺苷通路与钙稳态的串扰。
Rev Physiol Biochem Pharmacol. 2021;179:73-116. doi: 10.1007/112_2020_55.
本文引用的文献
1
Mechanosensitive channels in microbes.微生物中的机械敏感通道。
Annu Rev Microbiol. 2010;64:313-29. doi: 10.1146/annurev.micro.112408.134106.
2
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.Piezo1 和 Piezo2 是两种截然不同的机械激活阳离子通道的必需组成部分。
Science. 2010 Oct 1;330(6000):55-60. doi: 10.1126/science.1193270. Epub 2010 Sep 2.
3
C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.秀丽隐杆线虫 TRP 家族蛋白 TRP-4 是一种天然机械转导通道的孔形成亚基。
Neuron. 2010 Aug 12;67(3):381-91. doi: 10.1016/j.neuron.2010.06.032.
4
The role of the TRP channel NompC in Drosophila larval and adult locomotion.TRP 通道 NompC 在果蝇幼虫和成虫运动中的作用。
Neuron. 2010 Aug 12;67(3):373-80. doi: 10.1016/j.neuron.2010.07.004.
5
Canonical TRP channels and mechanotransduction: from physiology to disease states.经典型瞬时受体电位通道与机械转导：从生理学至疾病状态。
Pflugers Arch. 2010 Aug;460(3):571-81. doi: 10.1007/s00424-010-0847-8. Epub 2010 May 21.
6
Eukaryotic mechanosensitive channels.真核生物机械敏感性通道。
Annu Rev Biophys. 2010;39:111-37. doi: 10.1146/annurev.biophys.37.032807.125836.
7
Function and regulation of TRP family channels in C. elegans.TRP 家族通道在秀丽隐杆线虫中的功能和调节。
Pflugers Arch. 2009 Sep;458(5):851-60. doi: 10.1007/s00424-009-0678-7. Epub 2009 May 8.
8
The mechano-gated K(2P) channel TREK-1.机械门控钾离子（2P型）通道TREK-1
Eur Biophys J. 2009 Mar;38(3):293-303. doi: 10.1007/s00249-008-0318-8. Epub 2008 Mar 28.
9
TRP channels and mechanosensory transduction: insights into the arterial myogenic response.瞬时受体电位通道与机械感觉转导：对动脉肌源性反应的见解
Pflugers Arch. 2008 Jun;456(3):529-40. doi: 10.1007/s00424-007-0432-y. Epub 2008 Jan 5.
10
Mechanosensation.机械感觉
WormBook. 2006 Jan 6:1-14. doi: 10.1895/wormbook.1.62.1.
Zotero 插件