Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A STAR), 8A Biomedical Grove, Immunos, Biopolis, Singapore 138648, Singapore.
Curr Top Microbiol Immunol. 2012;351:1-24. doi: 10.1007/82_2010_115.
Dendritic cells (DCs) form a heterogeneous group of antigen presenting cells that play different roles in tissue immunity. Recent studies have revealed the presence of distinct DC populations in murine skin, highlighting the complexity of the cutaneous DC network. In this review, we will define the major DC subsets that populate the different layers of the skin, focusing on their origin and the mechanisms controlling their homeostasis. We will also review recent evidence underlining the functional specialization of dermal DC subsets and its relevance in the design of novel vaccine approaches.
树突状细胞（DCs）是一组异质性的抗原提呈细胞，在组织免疫中发挥不同的作用。最近的研究揭示了在鼠皮肤中存在不同的 DC 群体，突出了皮肤 DC 网络的复杂性。在这篇综述中，我们将定义分布在皮肤不同层的主要 DC 亚群，重点关注它们的起源和控制其稳态的机制。我们还将回顾最近的证据，强调皮肤 DC 亚群的功能特化及其在新型疫苗方法设计中的相关性。
