Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France.
Nat Rev Microbiol. 2013 Oct;11(10):701-12. doi: 10.1038/nrmicro3111.
Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into merozoites, the form that infects erythrocytes. This pre-erythrocytic phase is still the most enigmatic in the parasite life cycle, but has long been recognized as an attractive vaccination target. In this Review, we present what has been learned in recent years about the natural history of the pre-erythrocytic stages, mainly using intravital imaging in rodents. We also consider how this new knowledge is in turn changing our understanding of the immune response mounted by the host against the pre-erythrocytic forms.
疟疾是由疟原虫属引起的，它始于无症状期，在此期间，疟原虫孢子，即由蚊子注入皮肤的寄生虫形式，发育成裂殖子，即感染红细胞的形式。这个红细胞前期仍然是寄生虫生命周期中最神秘的阶段，但长期以来一直被认为是一个有吸引力的疫苗接种目标。在这篇综述中，我们介绍了近年来在使用啮齿动物活体成像技术研究红细胞前期阶段的自然史方面所学到的知识。我们还考虑了这些新知识如何反过来改变我们对宿主针对红细胞前期形式产生的免疫反应的理解。
