Kangwon National University School of Medicine, Gangwon-Do, Korea.
Nutr Cancer. 2010;62(8):1087-94. doi: 10.1080/01635581.2010.492088.
Ataxia telangiectasia mutated (ATM) cells exist under a constant state of oxidative stress with high levels of reactive oxygen species, which are removed by cellular antioxidant vitamins. We investigated the independent and combined effect of antioxidant vitamins intake and the ATM genotype or diplotype on the breast cancer risk. Analyses included 323 cases and age-matched controls who participated in the Korean Breast Cancer Study during 2001-2003 with complete dietary information. The vitamin A (P < 0.01) and α-tocopherol (P < 0.01) were associated with lower breast cancer risk as well as some water-soluble vitamins including vitamin B(2) (P = 0.01), vitamin C (P < 0.01), and folic acid (P = 0.02) intake. No five single nucleotide polymorphisms (ATM-5144A > T (rs228589), IVS21 + 1049T > C (rs664677), IVS33-55T > C (rs664982), IVS34+60G > A (rs664143), and 3393T > G (rs4585)) studied showed significant differences in their allele frequencies between the cases and controls. On the other hand, compared with the diploid of ATTGT/ATTGT, as the number of ATTGT haplotype decreased, the risk of breast cancer increased (P = 0.04). The association between ATM diplotype and the breast cancer risk was predominantly among women with low intake of antioxidant vitamins including vitamin A, vitamin C, and folic acid. This study suggested that some antioxidant vitamins intake may modify the effect of ATM diplotype on the breast cancer risk among Korean women.
共济失调毛细血管扩张症突变（ATM）细胞处于持续的氧化应激状态，活性氧水平较高，这些活性氧由细胞抗氧化维生素清除。我们研究了抗氧化维生素摄入以及 ATM 基因型或二倍型对乳腺癌风险的独立和联合影响。分析包括 2001-2003 年期间参加韩国乳腺癌研究的 323 例病例和年龄匹配的对照，他们具有完整的饮食信息。维生素 A（P<0.01）和α-生育酚（P<0.01）与较低的乳腺癌风险以及一些水溶性维生素（包括维生素 B2（P=0.01）、维生素 C（P<0.01）和叶酸（P=0.02））摄入有关。研究的五个单核苷酸多态性（ATM-5144A>T(rs228589)、IVS21+1049T>C(rs664677)、IVS33-55T>C(rs664982)、IVS34+60G>A(rs664143)和 3393T>G(rs4585))的等位基因频率在病例和对照组之间没有显著差异。另一方面，与 ATTGT/ATTGT 二倍体相比，随着 ATTGT 单倍型数量的减少，乳腺癌的风险增加（P=0.04）。ATM 二倍型与乳腺癌风险之间的关联主要存在于摄入维生素 A、维生素 C 和叶酸等抗氧化维生素水平较低的女性中。这项研究表明，一些抗氧化维生素的摄入可能会改变 ATM 二倍型对韩国女性乳腺癌风险的影响。
