TBHP/I2 介导的多米诺氧化环化一锅法合成多取代恶唑。
TBHP/I2-mediated domino oxidative cyclization for one-pot synthesis of polysubstituted oxazoles.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
出版信息
Org Lett. 2010 Dec 3;12(23):5561-3. doi: 10.1021/ol1023085. Epub 2010 Nov 8.
PMID:21058706
Abstract
A facile type of one-pot, transition-metal-free domino process was developed for the synthesis of oxazoles. Thus, a variety of polysubstituted oxazoles were easily synthesized via t-BuOOH/I(2)-mediated domino oxidative cyclization from readily available starting materials under mild conditions.
摘要
一种简便的一锅、无过渡金属的多米诺反应被开发用于合成恶唑。因此，通过 t-BuOOH/I(2)介导的多米诺氧化环化，从易得的起始原料在温和条件下很容易合成各种多取代恶唑。
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