Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, Rhode Island, USA.
Alcohol Clin Exp Res. 2011 Feb;35(2):194-202. doi: 10.1111/j.1530-0277.2010.01334.x. Epub 2010 Nov 8.
Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of "feeding-related" peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications.
越来越多的研究证据表明，酒精和食物寻求行为共享共同的神经通路。有临床前和临床证据表明，在动物和人类中，甜食的消费与酒精摄入有关。此外，越来越多的动物和人类文献表明，“与进食相关”的肽类物质参与了酒精寻求行为。特别是，中枢和外周食欲肽都显示出在酒精依赖中的可能作用。本综述将总结有关甜味偏好与酒精依赖之间的联系以及与进食相关肽类物质在酒精依赖中的作用的文献。具体来说，为了缩小研究范围，本综述将重点关注 2 种特定的途径，即中枢神经肽 Y 和外周肠道肽 ghrelin。尽管还需要更多的研究，但现有数据表明，研究酒精依赖中的与进食相关的途径可能具有理论、生物学、诊断和治疗意义。
